Reference

Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds

Relationship of molecular structure to in vivo scintigraphic distribution of carbon-11-labeled compounds. 4. Carbon-11-labeled mandelonitriles, mandelic acids and their esters. Winstead, Meldrum B.; Dougherty, Dennis A.; Lin, Tz-Hong; Khentigan, Archie; Lamb, James F.; Winchell, H. Saul (Bucknell Univ., Lewisburg, Pa., USA). J. Med. Chem., 21(2), 215-17 (English) 1978. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 25 Carbon 11-labeled p-methoxy- [33646-40-1], p-hydroxy- [13093-65-7] and 3,4-dihydroxymandelonitrile [51688-49-4] were prepd. from K 11CN and the appropriate benzaldehyde deriv.-bisulfite addn. product. Initial distribution of these nitriles after i.v. administration in dogs was primarily in the heart, liver, and kidneys, followed by rapid redistribution to the parotids and stomach with the hydroxy derivs. Carbon-11-labeled mandelic acid [90-64-2] and m-methyl- [65148-70-1], o-chloro- [10421-85-9], and p-chloromandelic acid [492-86-4], prepd. from the corresponding nitriles, when administered to dogs showed progressive renal excretion with activity accumulation in the bladder. Labeled Et [774-40-3] and benzylmandelate [890-98-2] showed initial accumulation in the lung with eventual excretion by the kidney.

An attempt to prepare a three-dimensional polymer with reversible linkages in all dimensions

An attempt to prepare a three-dimensional polymer with reversible linkages in all dimensions. Ramp, Floyd L. (BFGoodrich R and D Cent., Brecksville, OH 44141, USA). Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.), 24(2), 1-2 (English) 1983. CODEN: ACPPAY. ISSN: 0032-3934. DOCUMENT TYPE: Journal CA Section: 35 (Chemistry of Synthetic High Polymers) Condensation of phenols, i.e., p,p'-bisphenol (I) [92-88-6] or resorcinol [108-46-3], with mandelic acid [90-64-2] or p-chloromandelic acid [492-86-4] in H3PO4 at 140-180° in vacuum gave bislactones and monolactones in various proportion. 91097-13-1 are also occured in this study. The monolactones were easily coupled by oxidn. in acetone with KMnO4 and HOAc. Cu-catalyzed air oxidn. proceeded smoothly in HOAc with a trace of Cu(OAc)2 at room temp. to give dimers, except in the case of the monolactone [31617-41-1] from resorcinol. Cu-catalyzed air oxidn. of the bislactone [91097-15-3] and monolactone [91097-14-2] of I give oligomers with the structures II and III. An evaluation of the bond cleavage in the bislactones indicated that this linkage can probably be used to prep. 3-dimensional polymers with reversible linkages in all directions. .