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494-03-1

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Basic Information
CAS No.: 494-03-1
Name: chlornaphazine
Molecular Structure:
Molecular Structure of 494-03-1 (chlornaphazine)
Formula: C14H15Cl2N
Molecular Weight: 268.186
Synonyms: 2-Naphthalenamine, N,N-bis(2-chloroethyl)-;Chlornaphthin;Chloronaphthine;Aleukon;Chloronaftina;Chloronaphthina;Nafticlorina;Chlornaphazine;Chlornaphazin;Chlornaftina;Cloronaftina;
Density: 1.234g/cm3
Melting Point: 54-56°
Boiling Point: 414.3°C at 760 mmHg
Flash Point: 204.4°C
Safety: Confirmed human carcinogen producing bladder tumors. Human and experimental carcinogenic data. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
PSA: 3.24000
LogP: 4.12380
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Chemistry

IUPAC Name: N,N-Bis(2-Chloroethyl)naphthalen-2-amine
Synonyms: b-Naphthylbis(b-chloroethyl)amine ; b-Naphthyldi(2-chloroethyl)amine ; Di(2-Chloroethyl)-.beta.-naphthylamine ; Di(2-Chloroethyl)-b-naphthylamine ; Dichloroethyl-.beta.-naphthylamine
CAS NO: 494-03-1
Molecular Formula of N,N-Bis(2-Chloroethyl)-2-naphthylamine (CAS NO.494-03-1) : C14H15Cl2N
Molecular Weight of N,N-Bis(2-Chloroethyl)-2-naphthylamine (CAS NO.494-03-1) :268.1816
Molecular Structure of N,N-Bis(2-Chloroethyl)-2-naphthylamine (CAS NO.494-03-1) :
EINECS: 207-785-0
Index of Refraction: 1.63
Surface Tension: 47.1 dyne/cm
Density: 1.234 g/cm3
Flash Point: 204.4 °C
Enthalpy of Vaporization: 66.72 kJ/mol
Boiling Point: 414.3 °C at 760 mmHg
Vapour Pressure: 4.49E-07 mmHg at 25°C
Melting point: 54 ~ 56 °C.
Appearance:Colorless plates or brown solid.
Solubility: very slightly soluble in water, glycerol, soluble in petroleum ether, ethanol, olive oil, ethyl ether, benzene

Uses

 N,N-Bis(2-Chloroethyl)-2-naphthylamine (CAS NO.494-03-1) is used as anti-tumor drug.

Production

  N,N-Bis(2-Chloroethyl)-2-naphthylamine (CAS NO.494-03-1) is obtained from 2 - Amino-naphthalene as a raw material .

Toxicity Data With Reference

1.    

mmo-sat 40 µg/plate

     CNREA8    Cancer Research. 37 (1977),2209.
2.    

mma-sat 10 µg/plate

     PNASA6    Proceedings of the National Academy of Sciences of the United States of America. 72 (1975),5135.
3.    

dnd-dmg-orl 260 µmol/L

     CNREA8    Cancer Research. 30 (1970),195.
4.    

ipr-rat LD50:1086 mg/kg

     BCPCA6    Biochemical Pharmacology. 13 (1964),969.

Consensus Reports

IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 7 (1987),p. 130.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 4 (1974),p. 119.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man 4 (1974),p. 119.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Safety Profile

Confirmed human carcinogen producing bladder tumors. Human and experimental carcinogenic data. Moderately toxic by intraperitoneal route. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

Specification

1.Air & Water Reactions :Insoluble in water.
2.Reactivity Profile :chlornaphazine reacts with nucleophiles .
3.Fire Hazard: Flash point data are not available for chlornaphazine , but chlornaphazine is probably combustible.