Reference

Enhanced stabilizing effect of sodium gentisate on the hydrolysis of acetylacroninium perchlorate in aqueous solutions by freezing

Enhanced stabilizing effect of sodium gentisate on the hydrolysis of acetylacroninium perchlorate in aqueous solutions by freezing. Kreilgard, Bo (Dep. Pharm., Royal Danish Sch. Pharm., Copenhagen, Den.). Arch. Pharm. Chemi, Sci. Ed., 6(3), 116-20 Published in: Arch. Pharm. Chemi. 85(11), 608-12 (English) 1978. CODEN: AVPCCS. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Aq. solns. of acetylacroninium perchlorate (I) [58494-21-6] were stabilized by Na gentisate (II) [4955-90-2]. Hydrolysis of the pro-drug I at pH ￡ 8 was a spontaneous reaction between H2O and I which was slowed down by addn. of II to the soln. due to complex formation at 30°. In frozen samples at -5 to 10°, the rate of hydrolysis decreased due to crystn. of H2O resulting in enhanced stabilization of the pro-drug. The solns. were buffered with phosphate buffer pH = 6.5 and were kept in sealed ampuls in a thermostatically controlled bath, or were immersed in a CO2-Me2CO bath prior to placement at the appropriate temp.

Solubilization of water by hydrotropic salts

Solubilization of water by hydrotropic salts. Saleh, A. M.; Ebian, A. R.; Etman, M. A. (Fac. Pharm., Univ. Alexandria, Alexandria, Egypt). J. Pharm. Sci., 75(7), 644-7 (English) 1986. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The effect of some electrolytes, nonelectrolytes, surfactants, and hydrotropic salts on the soly. of H2O in 1-butanol [71-36-3] and 1-hexanol [111-27-3] was investigated. While NaCl and NaOAc decrease the soly. of water in 1-butanol, urea [57-13-6] has no significant effect. The ionic surfactants, Na lauryl sulfate [151-21-3] and cetrimide [8044-71-1], cause an initial decrease in the soly. of water in 1-butanol followed by an increase at high surfactant concns. The nonionic surfactant polysorbate 20 [9005-64-5], does not show the initial decrease in water soly. On the other hand, the hydrotropic salts, NaOBz [127-09-3], Na salicylate [54-21-7], and Na gentisate [4955-90-2], are the best water solubilizers in 1-butanol. Na salicylate showed the max. solubilizing power. The effect of NaOBz, Na salicylate, and Na lauryl sulfate on the soly. of water in 1-hexanol was also investigated. Similar results were obtained.