Reference

Identification of aminoglycoside antibiotics by NMR spectroscopy

Identification of aminoglycoside antibiotics by NMR spectroscopy. Kartashov, V. S.; Chernyshev, A. I.; Arzamastsev, A. P.; Esipov. S. E. (I MMI, Moscow, USSR). Khim.-Farm. Zh., 17(9), 1139-45 (Russian) 1983. CODEN: KHFZAN. ISSN: 0023-1134. 1263-89-4 and 1405-10-3 are also in the experiment. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 26, 64 Aminoglycoside antibiotics, streptomycin sulfate [3810-74-0], dihydrostreptomycin sulfate [5490-27-7] neomycin sulfate [1405-10-3], monomycin sulfate [1263-89-4], kanamycin sulfate [25389-94-0], tobramycin sulfate [49842-07-1], gentamycin sulfate [1405-41-0], and sisomycin sulfate [53179-09-2] were characterized by NMR. The spectra were run as 5% solns. in D2O on a pulsed 90 mHz spectrometer at 40°. The chem. shifts were measured by using Na 2,2-dimethyl-2-silapentane-5-sulfonate as the internal std. Signals corresponding to various protons in the antibiotics were identified by chem. shift and spin-spin coupling measurements. Structural proof for these antibiotics is given based on NMR measurements. .

Compatibility of furosemide with aminoglycoside admixtures

Compatibility of furosemide with aminoglycoside admixtures. Thompson, Dennis F.; Allen, Loyd V., Jr.; Desai, Sushama R.; Rao, Puskar S. (Dep. Pharm., State Oklahoma Teach. Hosp., Oklahoma City, OK 73126, USA). Am. J. Hosp. Pharm., 42(1), 116-19 (English) 1985. CODEN: AJHPA9. ISSN: 0002-9289. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The physicochem. interaction between furosemide (I) [54-31-9] injection 4 mL (40 mg) and admixts. of the aminoglycoside antibiotics amikacin sulfate [39831-55-5], gentamicin sulfate [1405-41-0], kanamycin sulfate [25389-94-0], netilmicin sulfate [56391-57-2], and tobramycin sulfate [49842-07-1] at 2, 1.6, 2, 1.5, and 1.6 mg/mL, resp., prepd. in 5% dextrose injection and 0.6% NaCl injection in minibags, was investigated to det. the compatibility of the drug combinations in minibags, the compatibility of 1:1 mixts. in usually administered concns., monitoring the pH changes during the administration of I to aminoglycoside soln., redissolving, purifying, and identifying the resultant ppts. I ppts. after addn. to admixts. contg. either gentamycin or netilmicin sulfates in both dextrose and NaCl injections, and therefore it is recommended that I be administered sep. or the i.v. tubing should be flushed thoroughly before and after administration of this drug via a Y-injection site.