Reference

Comparative effects of phenylbutazone, naproxen and flunixin meglumine on equine platelet aggregation and platelet factor 3 availability in vitro

Correction of: Comparative effects of phenylbutazone, naproxen and flunixin meglumine on equine platelet aggregation and platelet factor 3 availability in vitro. Johnstone, I. B. (Ontario Vet. Coll., Univ. Guelph, Guelph, ON N1G 2W1, Can.). Can. J. Comp. Med., 47(2), 172-9 (English) 1983. CODEN: CJCMAV. ISSN: 0008-4050. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Flunixin meglumine (I) [42461-84-7] (10-6M) significantly depressed the max. degree of ADP-induced (10-6M) aggregation while much higher concns. of phenylbutazone (II) [50-33-9] and naproxen (III) [22204-53-1] (5 ′ 10-5M) were required to produce similar effects. None of the nonsteroidal anti-inflammatory drugs significantly affected the duration of the lag phase or the initial velocity of ADP-induced aggregation within the range of drug concns. used (10-6-10-3M). 22204-53-1 and 42461-84-7 which are cas registry numbers of chemicals are mentioned. The lag phase and initial velocity of acid-sol. collagen-induced aggregation were significantly affected by 10-6M flunixin and 10-4M phenylbutazone or naproxen was required to produce equiv. effects. Concns. of 5 ′ 10-6M flunixin and 5 ′ 10-4M phenylbutazone or naproxen were required to significantly depress the degree of collagen-induced aggregation of horse platelets. Pretreatment of horse platelets with any of the nonsteroidal anti-inflammatory drugs (10-4M concn.) had no significant effect on ADP or collagen-induced blood platelet factor 3 [37270-93-2] availability. .

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods

Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods. Starosciak, Bohdan; Pachecka, Jan; Dobrzanski, Wladyslaw T.; Bicz, Wlodzimierz (Zakl. Mikrobiol. Farm., Akad. Med., Warsaw 02-007, Pol.). Farm.Several substances with their cas registry numbers 738-70-5 and 59-66-5 may be metioned in this study. Pol., 39(7), 399-402 (Polish) 1983. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) No mutagenic activity of astmopent [5874-97-5], Baclofen [1134-47-0], binazine [3778-76-5], chirurcoll [25154-80-7], chlorpropamide [94-20-2], clonazepam [1622-61-3], craviten [55769-64-7], diuramide [59-66-5], furosemide [54-31-9], glafenine [3820-67-5], mirenil [2376-43-4], sadamine [437-74-1], and salbutamol [18559-94-9] was obsd. in the microbial tests used. Metronidazole [443-48-1], biseptol [8064-90-2], trimethoprim [738-70-5], and butapirazole [50-33-9] were mutagenic, the latter, however, only at high concns. .