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| CAS No.: | 50-41-9 |
|---|---|
| Name: | Clomiphene Citrate |
| Article Data: | 2 |
| Molecular Structure: | |
|
|
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| Formula: | C26H28ClNO.C6H8O7 |
| Molecular Weight: | 598.093 |
| Synonyms: | Chloramiphene;Clomifene citrate (JP14);Clomivid;Ethanamine,2-[4-(2-chloro-1,2-diphenyl- ethenyl)phenoxy]-N,N-diethyl-,2-hydroxy-1,- 2,3-propanetricarboxylate (1:1);MRL-41;Clomid (TN);RMI 16312;Serophene citrate;2-[4-(2-chloro-1,2-diphenyl-ethenyl)phenoxy]-N,N-diethyl-ethanamine;Genozym;Clomphid;MRL 41;Fertyl;MER-41;Clomiphene dihydrogen citrate;Ikaclomin;Fertivet;Dyneric;Prestwick_757;Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, citrate;MER 41;clomifen dihydrogen citrate; |
| EINECS: | 200-035-3 |
| Melting Point: | 116.5-118 °C |
| Boiling Point: | 509 °C at 760 mmHg |
| Flash Point: | 261.6 °C |
| Solubility: | Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether. |
| Appearance: | crystalline solid |
| Hazard Symbols: |
 T
|
| Risk Codes: | 60-63 |
| Safety: | 53-36/37-45 |
| PSA: | 144.60000 |
| LogP: | 5.31410 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Structure of Clomifene citrate (CAS NO.50-41-9):
Molecular Formula: C32H36ClNO8
Molecular Weight :598.08
EINECS: 200-035-3
Melting point: 116.5-118°C
Boiling Point: 509 °C at 760 mmHg
Flash Point: 261.6 °C
Enthalpy of Vaporization: 77.94 kJ/mol
Vapour Pressure: 1.77E-10 mmHg at 25°C
storage temp.: 2-8°C
Appearance: Crystalline Solid
Product Categories: API;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Clomifene citrate (CAS NO.50-41-9): 1-(p-(beta-Diethylaminoethoxy)phenyl)-1,2-diphenyl-2-chloroethylene citrate ; 2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine citrate (1:1) ; Ardomon ; Chloramiphene ; Clomid ; Clomifeno ; Clomiphen-arcana ; Clomiphene citrate ; Clomiphene dihydrogen citrate ; Clomiphene-R ; Clomipheni citras ; Dyneric ; Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) ; Fertivet ; Fertyl ; Pergotime ; Racemic clomiphene citrate ; Tokormon
Uses
An unducer of ovulation. A gonad-stimulating principle.
Toxicity Data With Reference
| 1. | dnd-esc 25 mg/L | MUREAV Mutation Research. 165 (1986),57. | ||
| 2. | dni-esc 50 mg/L | MUREAV Mutation Research. 165 (1986),57. | ||
| 3. | orl-rat LD50:5750 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 9 (1966),44. | ||
| 4. | ipr-rat LD50:530 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 9 (1966),44. | ||
| 5. | orl-mus LD50:1700 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 3 (1969),187. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 172.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 551.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 , 1979,p. 551.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Safety Profile
Hazard Codes: 
T
Risk Statements: 60-63
R60:May impair fertility.
R63:Possible risk of harm to the unborn child.
Safety Statements: 53-36/37-45
S53:Avoid exposure - obtain special instructions before use.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: YE0875000
Moderately toxic by ingestion and intraperitoneal routes. Human reproductive effects by ingestion: changes in spermatogenesis and effects on testes, epididymis, and sperm duct. Human teratogenic effects by an unspecified route: developmental abnormalities of the eye and ear. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Used as a drug to induce ovulation and for the treatment of oligospermia. When heated to decomposition it emits very toxic fumes of Cl− and NOx.