Reference

Ocillographic polarography of ephedrine and several related derivatives

Ocillographic polarography of ephedrine and several related derivatives. Habermann, V.; Habermannova, S. (Med.In this study， 60-13-9 and 1197-21-3 are also used. Fak., Univ. Karlova, Plzen, Pol.). Farmakol. Toksikol. (Moscow), 47(2), 62-6 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 Ephedrine-HCl [50-98-6], methylephedrine-HCl [38455-90-2], dexphenmetrazine-HCl [63971-49-3], amphetamine sulfate [60-13-9], methylamphetamine [537-46-2], and phentermine-HCl [1197-21-3] at 10-4M and norephedrine-HCl [154-41-6] at 10-3M polarize in alk. medium (dropping Hg electrode) giving a break in the cathodic portion at a potential of -1.3 V to -1.5 V. At higher concns. such a polarizing effect was noted in the anodic part of the oscillogram. At high concn., the deformation in the oscillogram was quite pronounced suggesting adsorption of the active compds. on the electrode surface. The compds. could not be individually identified because of their close depolarization potential. These derivs. show a partial correlation between depolarization activity and hydrophobic properties. The presence of carboxyl and esp. phenolic groups sharply decreased the electrochem. active; DL-phenylalanine [150-30-1] and Pedrolon [140-36-3] were almost inactive. The presence of OH groups in the side chain do not substantially affect the depolarization effect. .

Studies on the utero-placental circulation

Studies on the utero-placental circulation. Kurosumi, Koji (Med. Sch., Osaka City Univ., Osaka, Japan). Sanfujinka No Shimpo, 25(2), 127-45 (Japanese) 1973. CODEN: SASHA5. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 2 Oxytocin [50-56-6] (0.25 IU, i.v. 5716-20-1 and 151-67-7 which are cas registry numbers of chemicals are mentioned.) given to pregnant rabbits increased intraamniotic fluid pressure and decreased uteroplacental circulation. Vasopressor drugs also decreased uteroplacental circulation in a dose-related manner, but ephedrine-HCl [50-98-6] was an exception and was without effect. Vasodilators such as isoproterenol-HCl (I) [51-30-9] decreased the uterine vascular resistance. The uteroplacental circulation was increased in animals anesthetized with halothane [151-67-7]. .