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CAS No.: | 500-28-7 |
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Name: | CHLORTHION |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C8H9 Cl N O5 P S |
Molecular Weight: | 297.656 |
Synonyms: | Phosphorothioicacid, O-(3-chloro-4-nitrophenyl) O,O-di-Me ester (6CI); BAY 22190; Chlorothion;Chlorthion; Chlorthion methyl; Compound 22/190; Methylchlorothion; NSC 8927;O,O-Dimethyl O-(3-chloro-4-nitrophenyl) thiophosphate; O,O-DimethylO-(3-chloro-4-nitrophenyl)thionophosphate; O,O-DimethylO-3-chloro-4-nitrophenyl phosphorothioate; O-(3-Chloro-4-nitrophenyl)O,O-dimethyl phosphorothioate; OMS 217 |
Density: | 1.499g/cm3 |
Melting Point: | 21° |
Boiling Point: | 366.6°Cat760mmHg |
Flash Point: | 175.5°C |
Solubility: | 40mg/L(20 oC) |
Hazard Symbols: | Xn,N |
Risk Codes: | R20/21/22; R50/53 |
Safety: | Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An insecticide. Decomposes and then ignites when heated above 270°C. When heated to decomposition it emits very toxic fumes of Cl−, SOx, POx, and NOx. |
PSA: | 115.41000 |
LogP: | 4.31810 |
The IUPAC name of Chlorthion (CAS NO.500-28-7):
(3-Chloro-4-nitrophenoxy)-dimethoxy-sulfanylidene-{5}-phosphane
Synonyms: 3-Chloro-4-nitrophenyldimethylphosphorothioate ; Bay 22190 ; Bay22190 ; Bay22190[qr] ; Bayer 22/190 ; Chloorthion ; Chloorthion[dutch] ; Chlorothion
CAS: 500-28-7
EINECS: 207-902-5
Molecular Formula: C8H9ClNO5PS
Molecular Structure:
Formula Weight: 297.65 g/mol
Index of Refraction: 1.586
Density: 1.499 g/cm3
Flash Point: 175.5 °C
Boiling Point: 366.6 °C at 760 mmHg
The toxicity of Chlorthion (CAS NO.500-28-7):
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 20mg/kg (20mg/kg) | Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986. | |
guinea pig | LD50 | intraperitoneal | 525mg/kg (525mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955. | |
guinea pig | LD50 | subcutaneous | 25mg/kg (25mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. |
mouse | LD50 | oral | 794mg/kg (794mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Archives of Toxicology. Vol. 41, Pg. 111, 1978. |
rabbit | LD50 | subcutaneous | 25mg/kg (25mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. |
rabbit | LDLo | oral | 1gm/kg (1000mg/kg) | Journal of Economic Entomology. Vol. 48, Pg. 139, 1955. | |
rat | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953. | |
rat | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953. |
rat | LD50 | oral | 285mg/kg (285mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. |
rat | LD50 | skin | 1500mg/kg (1500mg/kg) | World Review of Pest Control. Vol. 9, Pg. 119, 1970. | |
rat | LD50 | subcutaneous | 47mg/kg (47mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965. |
rat | LD50 | unreported | 880mg/kg (880mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 331, 1971. |
The Hazard Codes of Chlorthion (CAS NO.500-28-7): XnN
Risk Statements:R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:S13:Keep away from food, drink and animal foodstuffs. S60:This material and its container must be disposed of as hazardous waste. S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An insecticide. Decomposes and then ignites when heated above 270°C. When heated to decomposition it emits very toxic fumes of Cl−, SOx, POx, and NOx.