Detail of "500-55-0"

CAS Number:
500-55-0
Name:
Benzeneacetic acid, a-methylene-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Molecular Structure:
Formula:
C17H21 N O2
Molecular Weight:
271.39
Synonyms:
1aH,5aH-Tropan-3a-ol, atropate (ester) (8CI); Apoatropine (6CI,7CI); Benzeneacetic acid, a-methylene-,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-; Apoatropin; Apohyoscyamin;Apohyoscyamine; Atropamin; Atropamine; Atropyltropeine
Density:
1.13g/cm³
Boiling Point:
389.1°Cat760mmHg
Flash Point:
136.5°C
Safety:
Poison by ingestion and intraperitoneal routes. See also ESTERS. When heated to decomposition it emits toxic fumes of NO_x. An antispasmodic agent. Details

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Analytics and the stability of atropine sulfate and scopolamine hydrobromide: Analytics and the stability of atropine sulfate and scopolamine hydrobromide. Part 3: Studies on the stability of tropane alkaloids; part 80: Problems concerning the use of plastic containers for liquid pharmaceuticals. Jira, T.; Pohloudek-Fabini, R. (Sek. Pharm. 552-63-6 and 9002-88-4 are also occured in this study., Ernst-Moritz-Arndt-Univ., Greifswald DDR-2200, Ger. Dem. Rep.). Pharmazie, 38(8), 520-3 (German) 1983. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Degrdn. of atropine sulfate [55-48-1] and scopolamine-HBr [114-49-8] in aq. solns. involves hydrolysis, dehydration, and dimerization. In alk. solns. hydrolysis is the major mechanism of degrdn. The stability is affected most by pH, followed by temp. Buffering decreases stability and increased atropine degrdn. by dehydration to apoatropin [500-55-0]. When store at 20°, atropine sulfate solns. were most stable in polyethylene [9002-88-4] bottles, followed by clear glass ampuls; stability was lower in brown glass ampuls and bottles. Scopolamine-HBr behaved similarly in the long-term tests. TLC was used to identify the degrdn. products. The isothermal short-time test was not suitable for evaluating stability. .

Constituents in Tibetan traditional medicines: Constituents in Tibetan traditional medicines. Xiao, Peigen; He, Liyi; Wang, Liwei (Inst. Pharmacol., Chinese Acad. Med. Sci., Peop. Rep. China). Zhongyao Tongbao, 9(1), 10-11 (Chinese) 1984. CODEN: CYTPDT. 500-55-0 and 51-34-3 are also in the experiment. ISSN: 0254-0029. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Tropine [120-29-6], cuscohygrine [454-14-8], (-)6b-hydroxyhyoscyamine [55869-99-3], hyoscyamine [101-31-5], apoatropine [500-55-0], daturamine [52646-92-1] or scopolamine [51-34-3] contents in the root, leaf and (or) seed of Przewalskia tangutica, Scopolia tangutica, S. lurida, Hyoscyamus niger, Physochlaina praealta, Mandragora caulescens and M. chinghaiensis ranged from nondetectable to 3.82%. .