Reference

Tablets by a modified 'wet-granulation' technique

Tablets by a modified 'wet-granulation' technique. Rogerson, Alan George (Sterwin A.-G., Switz.). Eur. Pat. Appl. EP 100168 A2 8 Feb 1984, 51 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, IT, LI, LU, NL, SE. (English). (European Patent Organization).Some commonly used reagents like 5003-48-5 and 78-93-3 are used in this experiment. CODEN: EPXXDW. CLASS: IC: A61K009-16; A61K009-20. APPLICATION: EP 83-303935 6 Jul 1983. PRIORITY: GB 82-19487 6 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A modified wet granulation method (slurry granulator) is described for prepg. good quality tablets with high dosages of active ingredient and minimal excipients. One or more drugs and excipients are moistened with a predetd. amt. of nonsolvent granulating fluid to form a uniform, moist, coherent, nonpasty mass which is subdivided into individual granules and dried. The dried granules are compressed into tablets. The amt. of granulating fluid comprises 390% by wt. of the predetd. amt. of fluid so as to form a homogeneous slurry where the percentage by wt. of solids in the slurry is [total solids (both dissolved and undissolved) ′ 100/total slurry (fluids + total solids)] = 25% wt./wt. The remaining part of the particulate solid material is moistened by wet granulation with the slurry so as to form the desired pasty mass. Tablets were prepd. from (total quantity in mixt. in milligrams and amt. in slurry in grams given): DL-methionine [59-51-8] 250, 125; paracetamol [103-90-2] 500, -; PVP [9003-39-8] 30, 30; stearic acid 10, -; Na starch glycolate 50, -; and 200 mL H2O as granulating fluid. .

Effect of eterylate, benorylate and acetylsalicylic acid on glycemia in normal and experimental diabetic rats

Effect of eterylate, benorylate and acetylsalicylic acid on glycemia in normal and experimental diabetic rats. Alonso, S.; Ortega, M. P.; Armijo, M. (Dep. Invest., Lab. Alter, S.Several reagents with their cas registry numbers 5003-48-5 and 62992-61-4 are used here. A., Madrid, Spain). Arch. Farmacol. Toxicol., 9(2), 183-90 (Spanish) 1983. CODEN: AFTOD7. ISSN: 0304-8616. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of acetylsalicylic acid (I) [50-78-2] on blood sugar levels in normal and streptozotocin-diabetic rats were compared with those of its (acetylamino)phenyl ester, benorylate (II) [5003-48-5], and its [(acetylamino)phenoxy]ethyl ester, eterylate [62992-61-4], at equimolar doses. All 3 drugs had a hypoglycemic effect in diabetic animals when administered orally at a high dose (500 mg/100 g feed, calcd. as I), but only II decreased blood sugar levels in normal rats. .