CAS No.5006-20-2,5-Ethoxy-4-methyloxazole Suppliers

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Basic Information

Molecular Structure:
CAS No.:	5006-20-2
Name:	5-Ethoxy-4-methyloxazole
Article Data:	28

Formula:	C₆H₉NO₂
Molecular Weight:	127.143
Synonyms:	4-Methyl-5-ethoxyoxazole;
Density:	1.04 g/cm³
Boiling Point:	164.5 °C at 760 mmHg
Flash Point:	53.3 °C
Risk Codes:	36/37/38
Safety:	26-36/37/39
PSA:	35.26000
LogP:	1.38170

Synthetic route

: 23429-05-2
4-methyl-5-ethoxy-2-carboxyoxazole

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
With hydrogenchloride In chloroform at 50℃; pH=2.5;	94.8%
at 90℃; for 1h; Temperature;

: 23429-04-1
4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
Stage #1: 4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester With sodium hydroxide Stage #2: With hydrogenchloride	89.9%
With toluene-4-sulfonic acid; acetic acid In toluene at 90℃; for 3h; Solvent; Temperature; Reagent/catalyst;	93.7 %Chromat.
Stage #1: 4-methyl-5-ethoxy-2-oxazole carboxylate ethyl ester With sodium hydroxide In water Stage #2: With hydrogenchloride In water at 60 - 62℃; pH=2.5;

: 4289-99-0
ethyl N-formyl-2-aminopropanoate

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; magnesium oxide In dichloromethane at 120℃; for 8h; Reagent/catalyst; Temperature; Solvent; Sealed tube;	71%
With phosphorus pentoxide; magnesium oxide In chloroform for 20h; Heating;	50%
With phosphorus pentoxide In dichloromethane for 48h; Reflux;	50%

: 17344-99-9
AlaOEt

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.5 h / Reflux 2: phosphorus pentoxide; magnesium oxide / chloroform / 20.5 h / 20 °C / Inert atmosphere; Reflux View Scheme
Multi-step reaction with 2 steps 1: 2 h / 160 °C 2: 48 h / Reflux View Scheme

: 5774-26-5
methylglyoxal diethyl acetal

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1 h / 76 °C / Inert atmosphere 2: 2 h / 150 °C / Inert atmosphere View Scheme

: 1-bromo-1-ethoxyacetone

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
at 150℃; for 2h; Temperature; Inert atmosphere;	30.5 g

: 1-chloro-1-ethoxyacetone

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
at 130℃; for 2h; Temperature; Inert atmosphere;	28.5 g

: 23460-73-3
N-ethoxyoxalylalanine ethyl ester

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine; trichlorophosphate / toluene / 3 h / 55 - 110 °C 2: water; sodium hydroxide / 5 h / 50 - 55 °C / pH 14 3: 1 h / 90 °C View Scheme
With triethylamine; Triphenylphosphine oxide; trichloromethyl chloroformate In dichloromethane at 0 - 50℃; for 2.5h; Reagent/catalyst; Solvent;	97 %Chromat.

: 4-methyl-5-ethoxyoxazole butyl carboxylate

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; acetic acid In 1,4-dioxane at 90℃; for 2h; Reagent/catalyst; Solvent;	93.7 %Chromat.

: hexyl 4-methyl-5-ethoxyoxazolecarboxylate

: 5006-20-2
5-ethoxy-4-methyl-oxazole

Conditions

Conditions	Yield
With sodium acetate; benzoic acid In acetonitrile at 90℃; for 2h;	40.2 %Chromat.

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Specification

The 5-Ethoxy-4-methyloxazole with the cas number 5006-20-2, is also called 4-Methyl-5-ethoxyoxazole. 5-Ethoxy-4-methyloxazole belongs to the following product categories: Oxazole and Isoxazole. Raw material of 5-Ethoxy-4-methyloxazole are as the following: (1)Chloroform; (2)Phosphorus pentoxide; (3)Formamide; (4)L-Alanine; (5)Ethyl 2-aminopropanoate hydrochloride

Properties of 5-Ethoxy-4-methyloxazole are as the following: (1)H bond acceptors: 3 ; (2)H bond donors: 0 ; (3)Freely Rotating Bonds: ; (4)2 Polar Surface Area: 35.26 Å ; (5)Index of Refraction: 1.448 ; (6)Molar Refractivity: 32.78 cm³ ; (7)Molar Volume: 122.2 cm³ ; (8) Polarizability: 12.99 ×10^-24cm³; (9)Surface Tension: 31.4 dyne/cm ; (10)Density: 1.04 g/cm³ ; (11)Flash Point: 53.3 °C ; (12)Enthalpy of Vaporization: 38.45 kJ/mol ; (13)Boiling Point: 164.5 °C at 760 mmHg ; (14)Vapour Pressure: 2.58 mmHg at 25°C

You can still convert the following datas into molecular structure :
1. SMILES: O(c1ocnc1C)CC
2. SMILES: InChI=1/C6H9NO2/c1-3-8-6-5(2)7-4-9-6/h4H,3H2,1-2H3

The 5-Ethoxy-4-methyloxazole can react with methanol and 3c-chloro-acrylic acid to generate 2-methyl-3-hydroxy-4-carboxy-6-methoxypyridine under ambient temperature, with productivity 33 % .

The 5-Ethoxy-4-methyloxazole can also react with phenylpropynoic acid ethyl ester to generate 2-ethoxy-4-phenyl-furan-3-carboxylic acid ethyl ester in toluene for 3 hour heating. Productivity is around 90 % .