Reference

Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats

Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats. Misumi, J.; Nagano, M. (Med. Sch., Kumamoto Univ., Kumamoto 860, Japan). Br. J. Ind. Med., 41(4), 526-32 (English) 1984. CODEN: BJIMAG. ISSN: 0007-1072. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) To det. the specific structural properties responsible for neurotoxic activity, the comparative neurotoxicity of n-hexane [110-54-3], Me Bu ketone [591-78-6], 2,5-hexanedione [110-13-4], and their relatives was investigated in the peripheral nerves of rats. The max. conduction velocity of motor and sensory fibers and the motor distal latency of the tail nerves of rats were periodically examd. in animals receiving repeated s.c. injections of 11 aliph. monoketone or diketone compds. and their relatives for prolonged periods. A study of the comparative neurotoxicity of n-hexane, Me Bu ketone, and their metabolites showed that 2,5-hexanedione was the most actively neurotoxic. Furthermore, a study of other sym. diketones with different C nos. showed that 2,4-pentanedione [123-54-6], which is structurally similar to 2,5-hexanedione, possessed a different type of neurotoxic activity than 2,5-hexanedione. Regarding aliph. monoketone compds., acetone [67-64-1], 2-pentanone [107-87-9], 2-heptanone [110-43-0], and 2-octanone [111-13-7] were confirmed nonneurotoxic for the peripheral nervous system. Evidence from some previous reports, however, suggested that 3-heptanone [106-35-4], 4-octanone [589-63-9], and 5-nonanone [502-56-7] might produce neuropathies by being converted to 2,5-diketones under specific conditions.

Cleaner solutions

Cleaner solutions. (Carbon Paper Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 58225200 A2 27 Dec 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C11D007-50. APPLICATION: JP 82-107476 21 Jun 1982. DOCUMENT TYPE: Patent CA Section: 46 (Surface Active Agents and Detergents) Cleaner solns. for removing soil and graffiti from plastic and other surfaces are prepd. by mixing 2-pyrrolidinone [616-45-5] or a deriv. and(or) mesityl oxide [141-79-7] (good solvents) with an ester and(or) a ketone and with a poor solvent (e.g., water or hydrocarbon). A typical compn. comprised Methyl Carbitol [111-77-3] 1, Bu2CO [502-56-7] 1.5, N-vinylpyrrolidinone [88-12-0] 1.8, kerosine (b. 90-180°) 9, and sec-BuOH [78-92-2] 3 parts.