Reference

1-b-D-Arabinofuranosylcytosine 5'-(3-carboxypropyl) phosphate

1-b-D-Arabinofuranosylcytosine 5'-(3-carboxypropyl) phosphate. (Yamasa Shoyu Co., Ltd., Japan). Jpn.Chemicals with cas numbers 502-85-2 and 89142-98-3 also play role. Kokai Tokkyo Koho JP 58206600 A2 1 Dec 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07H019-10. ICA: A61K031-70. APPLICATION: JP 82-90944 27 May 1982. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 1 The title compd. (I) was prepd. by condensation of N4,O2',O3'-triacetyl-1-b-D-arabinofuranosylcytosine 5'-monophosphate (II) with HO(CH2)3CO2H (III) in the presence of tosyl chloride (IV) followed by deacetylation. Anticarcinogenic data on I against mouse leukemia cells are given. Thus, 20 mmol IV was added to a mixt. of 10 mmol II Bu3N salt and 20 mmol III Na salt in pyridine, the whole kept 20 h at room temp., deacetylated with aq. NH3, and chromatographed over Dowex 1 ′ 5 (HCO2H) to give 1.4 g I. .

Nootropic activity of some GABA derivatives

Nootropic activity of some GABA derivatives. Ostrovskaya, R. U.; Trofimov, S. S. (Inst. Pharmacol.Chemicals with cas numbers 502-85-2 and 61742-10-7 also play role., Moscow, USSR). Byull. Eksp. Biol. Med., 97(2), 170-2 (Russian) 1984. CODEN: BEBMAE. ISSN: 0365-9615. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Antiamnesic and antihypoxic effects of GABA and its derivs. cetyl GABA, phenibut, baclofen, g-hydroxybutyric acid, Na hydroxybutyrate, and Li hydroxybutyrate were studied in rats and mice and were compared with the effects of piracetam, depakine, a-ketoglutarate, and diphenylhydantoin. Cetyl GABA, the hydroxybutyrate salts, and phenibut decreased retrograde amnesia caused by electroshock in passive avoidance performance in rats. These compds. were as effective as the std. piracetan. The antihypoxic effects of Na hydroxybutyrate, cetyl GABA, phenibut, and baclofen were similar to those of piracetam. These GABA derivs. were effective at concns. which did not provoke muscle relaxation or cause central nervous system depression. Thus, noncyclic GABA derivs. as well as the cyclic deriv. piracetam produced nootropic effects. .