Reference

Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat

Enhancement of renal medulla prostaglandin synthetase activity by dexamethasone treatment in the rat. Erman, A.; Nasjletti, A. (Dep. Pharmacol., Univ. Tennessee, Memphis, TN 38163, USA). Biochem. Biophys. Res. Commun., 121(1), 255-60 (English) 1984. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 6 Administration of dexamethasone [50-02-2] (2.5 mg/kg/wk, s.c.) to rats did not affect the rate of conversion of arachidonic acid [506-32-1] to prostaglandins by renal medulla slices, but significantly increased the rate of conversion by both microsomes and the 10,000g supernatant of renal medulla homogenates. Evidently, the dexamethasone treatment increases the activity of renal medulla prostaglandin synthetase [9055-65-6] measured in broken cells prepns., and such a change in enzyme activity is not manifested by augmentation of prostaglandin synthesis in renal medulla slices incubated with exogenous arachidonic acid.

Prophylactic substance or composition

Prophylactic substance or composition. Booyens, Jakobus (Sentrachem Ltd., S. Afr.). Ger. Offen. DE 3334323 A1 29 Mar 1984, 35 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-557; A23L001-30. APPLICATION: DE 83-3334323 22 Sep 1983. PRIORITY: ZA 82-6965 22 Sep 1982. DOCUMENT TYPE: Patent CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 The growth of tumor cells was inhibited by the addn. of compds. which are precursors for the formation of eicosanoids. g-Linolenic acid [506-26-3], arachidonic acid [506-32-1], and(or) eicosapentaenoic acids are suitable precursors for this purpose. Formulations and prophylactic uses of such compds. are discussed.