Detail of "50646-98-5"

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Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus

Screening for inhibitors of avian myeloblastosis virus reverse transcriptase and effect on the replication of AIDS virus. Inouye, Yoshio; Take, Yukinori; Nakamura, Shoshiro; Nakashima, Hideki; Yamamoto, Naoki; Kawaguchi, Hiroshi (Sch. Med., Hiroshima Univ., Hiroshima 734, Japan). J. Antibiot., 40(1), 100-4 (English) 1987. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Among several antibiotics tested, the peptides janiemycin [50646-98-5], colistin [1066-17-7], and enduracidin A [34438-27-2] and B [34304-21-7] were all potent inhibitors of com. available avian myeloblastosis virus reverse transcriptase [9068-38-6]. The luzopeptins were particularly active. However, these 3 drugs, luzopeptin A [75580-37-9], B [76149-24-1], and C [76110-01-5], were also markedly cytotoxic to L5178Y cells in vitro. The replication of the AIDS-causing human immunodeficiency virus (HIV) in MT-4 cells was suppressed by luzopeptin C at concns. of 2. 1066-17-7 and 11056-06-7 which are cas registry numbers of substances are two of reagents here.5-5.0 mg/mL. The effect of streptonigrin amide [99520-46-4] and streptonigrin glycine [99533-82-1] on HIV replication and the reverse transcriptase-inhibiting activity and cytotoxicity of various bleomycins is also reported. .