CAS No.50679-08-8,Terfenadine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	50679-08-8
Name:	Terfenadine
Article Data:	13

Formula:	C₃₂H₄₁NO₂
Molecular Weight:	471.683
Synonyms:	Allerplus;Histadin;Histafen;MDL 9918;NSC 665802;Nebralin;Racemic terfenadine;Seldane;Teldane;Terdin;Terfex;Terfinax;Ternadin;Triludan;dl-Terfenadine;a-(p-tert-Butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol;Cyater;
EINECS:	256-710-8
Density:	1.088 g/cm³
Melting Point:	145-152 °C
Boiling Point:	626.8 °C at 760 mmHg
Flash Point:	306.9 °C
Solubility:	Very slightly soluble in cold water
Appearance:	white solid
Safety:	24/25
PSA:	43.70000
LogP:	6.38370

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Chemistry

IUPAC Name: 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)Methyl]piperidin-
1-yl]butan-1-ol (256-710-8)
Synonyms: Alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol ; Terfenadine ; 1-(4-tert-butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-Butan-1-ol ; 1-(4-tert-Butylphenyl)-4-(4-[hydroxy(diphenyl)methyl]-1-piperidinyl)-1-Butanol ; 1-(p-tert-butylphenyl)-4-(4’-(alpha-hydroxydiphenylmethyl)-1’-piperidyl)-Butan ; 1-Piperidinebutanol, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- ; 1-piperidinebutanol,alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmeth ; Aldaban
CAS: 50679-08-8
Molecular formula: C₃₂H₄₁NO₂
Molecular weight: 471.67
Molecular structure:
EINECS: 256-710-8
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor
Mol File: 50679-08-8.mol
Surface Tension: 46.1 dyne/cm
Density: 1.088 g/cm³
Flash Point: 306.9 °C
Melting point: 145-152 °C
Enthalpy of Vaporization: 97.53 kJ/mol
Boiling Point: 626.8 °C at 760 mmHg
Vapour Pressure: 1.41E-16 mmHg at 25°C
Storage temp: 2-8°C
Water Solubility : 0.001 g/100 mL (30 ºC)
Appearance: Teldane (50679-08-8) is white solid .

Uses

Teldane (50679-08-8) belongs to antihistamines,and is used for allergic rhinitis, urticaria, allergic skin diseases.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	3mg/kg (3mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure"	British Medical Journal. Vol. 293, Pg. 536, 1986.
dog	LD	oral	> 1500mg/kg (1500mg/kg)	gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 845, 1986.
guinea pig	LD50	oral	> 2gm/kg (2000mg/kg)		Merck Index. Vol. 11, Pg. 1443, 1989.
human	TDLo	oral	857ug/kg (0.857mg/kg)	behavioral: somnolence (general depressed activity) behavioral: alteration of operant conditioning behavioral: changes in psychophysiological tests	European Journal of Clinical Pharmacology. Vol. 47, Pg. 331, 1994.
mammal (species unspecified)	LD50	intraperitoneal	43mg/kg (43mg/kg)		Journal of Medicinal Chemistry. Vol. 38, Pg. 2472, 1995.
man	TDLo	oral	857ug/kg (0.857mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure"	British Medical Journal. Vol. 293, Pg. 536, 1986.
man	TDLo	oral	36mg/kg/3W-I (36mg/kg)	liver: "jaundice, cholestatic" liver: liver function tests impaired	Lancet. Vol. 348, Pg. 552, 1996.
man	TDLo	oral	156mg/kg/13W- (156mg/kg)	skin and appendages (skin): hair: other	British Medical Journal. Vol. 291, Pg. 940, 1985.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		United States Patent Document. Vol. #4908365,
mouse	LD50	oral	5gm/kg (5000mg/kg)		Pharmacy International. Vol. 4, Pg. 252, 1983.
mouse	LD50	subcutaneous	> 4500mg/kg (4500mg/kg)		Drugs in Japan Vol. -, Pg. 707, 1990.
rat	LD50	intraperitoneal	154mg/kg (154mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
rat	LD50	oral	5gm/kg (5000mg/kg)		Pharmacy International. Vol. 4, Pg. 252, 1983.
rat	LD50	subcutaneous	> 1250mg/kg (1250mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
women	TDLo	oral	1200ug/kg (1.2mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure"	British Medical Journal. Vol. 293, Pg. 536, 1986.
women	TDLo	oral	190mg/kg/23W- (190mg/kg)	behavioral: muscle weakness liver: "jaundice, other or unclassified" liver: liver function tests impaired	Annals of Internal Medicine. Vol. 103, Pg. 634, 1985.

Safety Profile

Safety Statements: 24/25
24/25: Teldane (50679-08-8) is toxic in contact with skin and if swallowed
WGK Germany: 2
RTECS: TM4969000

Specification

1.Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container.
2..Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
3.Storage: Store Teldane (50679-08-8) in a cool, dry place. Store in a tightly closed container.