Products Categories
| CAS No.: | 508-75-8 |
|---|---|
| Name: | CONVALLATOXIN |
| Article Data: | 4 |
| Molecular Structure: | |
|
|
|
| Formula: | C29H42 O10 |
| Molecular Weight: | 550.646 |
| Synonyms: | Convallatoxin(6CI,7CI,8CI); Convallaotoxin; Convallaton; Convallatoxine; Convallatoxoside;Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; NSC 407808;Strophanthidin a-L-rhamnoside |
| EINECS: | 208-086-3 |
| Density: | 1.41 g/cm3 |
| Melting Point: | 238-239℃ (water ) |
| Boiling Point: | 757.3 °C at 760 mmHg |
| Flash Point: | 247.1 °C |
| Safety: | Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes. |
| PSA: | 162.98000 |
| LogP: | 0.75000 |
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 958254-66-51H-Imidazo[4,5-b]pyridine-2-carboxaldehyde, 1-methyl-, hydrochloride
- 99170-93-1N-Methyl-2-oxazolamine
- 717878-06-31-(4-fluorophenyl)-4-nitro-1H-imidazole
- 914458-26-7[5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-Methanone
- Total:33 Page 1 of 1 1
What can I do for you?
Get Best Price
Chemistry
Product Name: Convallatoxin (CAS NO.508-75-8)
Molecular Formula: C29H42O10
Molecular Weight: 550.64g/mol
Mol File: 508-75-8.mol
Einecs: 208-086-3
Boiling point: 757.3 °C at 760 mmHg
Flash Point: 247.1 °C
Density: 1.41 g/cm3
Surface Tension: 70.3 dyne/cm
Enthalpy of Vaporization: 125.86 kJ/mol
Vapour Pressure: 1.8E-26 mmHg at 25°C
XLogP3: -0.7
H-Bond Donor: 5
H-Bond Acceptor: 10
Uses
Convallatoxin (CAS NO.508-75-8) is a cardiac drug, similar to digitalis. It is mainly used for acute and chronic heart failure.
Production
Lily of the valley on the grass part of the whole meal with benzene - ethanol mixture solvent extraction, extract concentration and then with chloroform - ethanol solution of concentrated liquid extract, in turn extracts concentrated, the concentrated solution of water extraction. Concentrated aqueous solution obtained after the cooling, crystallization of a lily of the valley poisoning glycosides crude, crude product recrystallized with methanol that was finished, the lily of the valley-wide grass meal, total yield of 0.01%.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD50 | intraduodenal | 2100ug/kg (2.1mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| cat | LD50 | intraperitoneal | 180ug/kg (0.18mg/kg) | Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964. | |
| cat | LD50 | intravenous | 74ug/kg (0.074mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942. | |
| cat | LD50 | oral | 3650ug/kg (3.65mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| cat | LDLo | unreported | 50ug/kg (0.05mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964. | |
| frog | LD50 | subcutaneous | 440ug/kg (0.44mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| frog | LDLo | intravenous | 300ug/kg (0.3mg/kg) | Merck Index. Vol. 10, Pg. 357, 1983. | |
| guinea pig | LD50 | intraperitoneal | 200ug/kg (0.2mg/kg) | Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964. | |
| guinea pig | LD50 | intravenous | 185ug/kg (0.185mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| guinea pig | LD50 | oral | > 50mg/kg (50mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| guinea pig | LD95 | intraduodenal | 10490ug/kg (10.49mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| monkey | LDLo | intravenous | 90ug/kg (0.09mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963. | |
| mouse | LD50 | intraperitoneal | 10mg/kg (10mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965. | |
| mouse | LD50 | intravenous | 1mg/kg (1mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00462, | |
| mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958. | |
| mouse | LD50 | subcutaneous | 15mg/kg (15mg/kg) | Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981. | |
| pig | LDLo | intraduodenal | 3170ug/kg (3.17mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970. | |
| pig | LDLo | intravenous | 50ug/kg (0.05mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970. | |
| pigeon | LDLo | intravenous | 248ug/kg (0.248mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963. | |
| rat | LD50 | intravenous | 15200ug/kg (15.2mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961. |
Safety Profile
Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.
Specification
Convallatoxin ,its CAS NO. is 508-75-8,the synonyms is Strophanthin 3alpha-1-rhamnoside ; Strophanthidin alpha-l-rhamnopyranoside ; Strophanthidin a-l-rhamnopyranoside ; Corglykon ; Convallatoxin;20(22),5beta-cardenolid-19-al-3beta,5beta,14beta-triol-3beta-d-[a-1-rhamnopyranoside] ; 5Beta,20[22]-cardenolide-19-one-3beta,5alpha,14-triol-3-[6-deoxy-alpha-l-mannopyranosyl] ; 3Beta,5alpha,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide-3-[6-deoxy-alpha-l-mannopyranosyl] .