Detail of "50899-10-0"

Reference

Long-acting dihydropyridine calcium antagonists

Long-acting dihydropyridine calcium antagonists. 9. Structure activity relationships around amlodipine. Alker, D.; Arrowsmith, J. E.; Campbell, S. F.; Cross, P. E. (Pfizer Cent. Res., Sandwich/Kent CT13 9NJ, UK). Eur. J. Med. Chem., 26(9), 907-13 (English) 1991. CODEN: EJMCA5. ISSN: 0223-5234. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Phenylpyridinedicarboxylates I (R1 = Me, Et, MeOCH2CH2, etc., R2 = Et, Me, CMe3, CH2CF2CF3, etc. 140171-65-9 and 50899-10-0 which are cas registry numbers of substances are two of reagents here., R3 = Me, CH2OMe, CH2SMe, CF3, cyano, CH2OCMe3, R4 = H, X = H, Cl) were prepd. and their calcium channel blocking activity and structure activity relationships were examd. Thus, condensation of R3C(NH2):CHCO2R1 with [(phthalimido)ethoxy]acetoacetates II and 2-ClC6H4CHO or 2,3-Cl2C6H3CHO gave I (NR42 = phthalimido) which were deprotected to give the free amine. Increasing the size of the C5 ester group dramatically reduces calcium antagonist activity. .

Substituted 1,4-dihydropyridines and their use in treating cardiovascular diseases

Substituted 1,4-dihydropyridines and their use in treating cardiovascular diseases. Schoenafinger, Karl; Beyerle, Rudi; Martorana, Piero A.; Just, Melitta; Bohn, Helmut (Cassella A.-G.Several substances are used for example 50899-10-0 which is its cas registry number., Fed. Rep. Ger.). Ger. Offen. DE 3303066 A1 6 Dec 1984, 37 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D211-90; C07D401-06; C07D401-04; C07D405-04; A61K031-44. APPLICATION: DE 83-3303066 29 Jan 1983. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 63 Title compds. (I) (R = aryl, heteroaryl, etc.; R1 = piperidyl deriv.,. alkyl, etc.; R2-4 = H, alkyl, aryl, etc.; R5 = piperidyl deriv.) were prepd. as coronary vasodilators (no data). Thus, 2.0 g 3-O2NC6H4CHO, 5.3 g 1-methyl-4-piperidyl acetoacetate, 1.8 g concd. aq. NH3, and 35 mL Me2CHOH were refluxed 3.5 h to give 2.0 g title compd. II. .