Detail of "509-80-8"

Reference

Oxindolic alkaloids from Uncaria orientalis Guill

Oxindolic alkaloids from Uncaria orientalis Guill. (Rubiaceae). Croquelois, G.; Miet, C.; Poisson, J.; Sevenet, T. (Cent. Etud. Pharm., Chatenay-Malabry, Fr.). Ann. Pharm. Fr., 35(9-10), 417-18 (French) 1977. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 11 (Plant Biochemistry) (-)-Mitraphylline [509-80-8], uncarine E [5171-37-9], isomitraphylline [4963-01-3], isorynchophylline [6859-01-4], and rhynchophylline [76-66-4] were identified in Na2CO3 (10% soln.) exts. of U. orientalis.

Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Ab1-40)

All Rights Reserved. Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Ab1-40). Frackowiak, Teresa; Baczek, Tomasz; Kaliszan, Roman; Zbikowska, Beata; Glensk, Michal; Fecka, Izabela; Cisowski, Wojciech ( Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gdansk 80-416, Pol.). Zeitschrift fuer Naturforschung, C: Journal of Biosciences, 61(11/12), 821-826 (English) 2006 Verlag der Zeitschrift fuer Naturforschung. CODEN: ZNCBDA.Chemical with cas number 509-80-8 also plays role. ISSN: 0939-5075. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The primary aim of this work was to det. the interactions of an oxindole alkaloid (mitraphylline) isolated from Uncaria tomentosa with b-amyloid 1-40 (Ab1-40 protein) applying the capillary electrophoresis (CE) method. Specifically the Hummel-Dreyer method and Scatchard anal. were performed to study the binding of oxindole alkaloids with Ab1-40 protein. Prior to these studies extn. of the alkaloid of interest was carried out. Identification of the isolated alkaloid was performed by the use of thin-layer chromatog. (TLC) and high-performance liq. chromatog. (HPLC) combined with electrospray ionization mass spectrometry (ESI-MS). The proposed approach was proved to be an efficient and accurate method for specific compd. isolation and identification purposes. Moreover, anal. information from the CE approach can be considered as the valuable tool for binding const. detn. The binding const. of mitraphylline with Ab1-40 protein detd. by the Hummel-Dreyer method and Scatchard anal. equals K = 9.95 ′ 105 M-1. The results obtained showed the significant binding of the tested compd. with Ab1-40 protein. These results are discussed and interpreted in the view of developing a strategy for identification of novel compds. of great importance in Alzheimer disease therapy. .