Detail of "50995-48-7"

Reference

A manufacturing of 1,2-disubstituted hexahydropyridazine-3-carboxylic acid derivatives

A manufacturing of 1,2-disubstituted hexahydropyridazine-3-carboxylic acid derivatives. Nerenz, Frank; Bartels, Guenter; Kanschik-Conradsen, Andreas ( Honeywell Specialty Chemicals Seelze GmbH, Germany). PCT Int. Appl. WO 2005028449 A1 31 Mar 2005, 22 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D237-04. APPLICATION: WO 2004-EP5284 17 May 2004. PRIORITY: DE 2003-10328888 26 Jun 2003; US 2003-PV505470 24 Sep 2003. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 45 The invention relates to an improved process for the manuf. of 1,2-disubstituted hexahydro-pyridazine-3-carboxylic acid derivs. 50995-48-7 is the cas registry number of certain chemical which is used as reagents here. of formula I [wherein: Z is identical or different amino-protecting group; R is represents independently from each other H, alkyl, aryl, or arylalkyl, etc.; R1 is carboxylic or ester group] via reaction of N,N'-disubstituted hydrazine with 2,5-dihalogenated valeric acid. The invention compds. are useful as intermediates for the prodn. of pharmaceutical products. For instance, pyridazine deriv. II was prepd. via heterocyclization of N,N'-dibenzyloxycarbonyl-hydrazine with Me 2-bromo-5-chlorovalerate in acetonitrile with a yield of 87%. .