Detail of "51-34-3"

Reference

Effects of scopolamine and nicotine on human rapid information processing performance

Effects of scopolamine and nicotine on human rapid information processing performance. Wesnes, Keith; Warburton, David M. (Dep. Psychol., Univ. Reading, Reading RG6 2AL, UK). Psychopharmacology (Berlin), 82(3), 147-50 (English) 1984. CODEN: PSCHDL. ISSN: 0033-3158.There are some reagents with their cas registry numbers 54-11-5 and 13265-10-6 are used in this study. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 After a 10-min baseline test on a rapid information-processing task, subjects received oral doses of either placebo, methscopolamine [13265-10-6] 1.2 mg, scopolamine [51-34-3] 0.6 mg, or scopolamine 1.2 mg, and 1 h later performed the task again for a 20-min period. Following scopolamine 1.2 mg, correct detections were significantly lower over the 20-min period, whereas no such decrement was obsd. in the other 3 conditions. In a 2nd expt., a similar design was used to study the effects of nicotine [54-11-5] 0.5 mg, 1.0 mg, and 1.5 mg and placebo, except that post-drug testing was carried out 10 min after baseline, due to the faster absorption of nicotine. Nicotine helped prevent both the decline in detections and the increase in reaction time which occurred over time in the placebo condition. Thus, compds. with opposite effects on central cholinergic pathways produce opposite effects on the performance of a task involving rapid information processing, and are consistent with previous findings from this lab. .

Scopolamine-induced anesthesia and monoamine transmitters in the brain

Scopolamine-induced anesthesia and monoamine transmitters in the brain. Dai, Dezai; Ma, Junru; Wang, Yuzu; Zhang, Hui (Div. Pharmacol., Nanjing Coll. Pharm., Nanjing, Peop. Rep. China). Nanjing Yaoxueyuan Xuebao, (2), 1-6 (Chinese) 1983. CODEN: NYXUDF. ISSN: 0254-5055. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The levels, of 5-HT [50-67-9] and 5-HIAA [54-16-0] in rat brain were increased during anesthesia induced by scopolamine [51-34-3] intracerebroventricularly. The duration of anesthesia from scopolamine in mice was prolonged by L-tryptophan [73-22-3] (400 mg/kg i.p.).There are some commonly used reagents with their cas registry numbers 54-16-0 and 51-61-6 in this article. Anesthesia was not abolished by depletion of 5-HT and 5-HIAA in rat brain by p-chlorophenylalanine. The levels of dopamine [51-61-6] in midbrain were increased but no significant change in noradrenaline [51-41-2] levels were obsd. Stimulation of 5-HT system in rat brain had synergistic effect with scopolamine. The transmitting function of tryptophanergic neurons in the brain might be accelerated by M-cholinergic receptor. .