Detail of "51-75-2"

Reference

Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogs

Protection of murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine and inhibition of choline uptake as a structure-activity relationship of 2-dimethylaminoethanol and its analogs. Naujokaitis, Saulius A.; Fisher, Joyce M.; Rabinovitz, Marco (Lab. Med. Chem. Pharmacol., Natl. Cancer Inst.There are some reagents with their cas registry numbers 100-37-8 and 102-81-8 are used in this study., Bethesda, MD 20850, USA). J. Pharm. Sci., 73(1), 34-9 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The structure-activity relationships of 2-dimethylaminoethanol [108-01-0] and its analogs as protectors against mechlorethamine [51-75-2] cytotoxicity and as inhibitors of choline [62-49-7] uptake were evaluated. Of a series of inhibitors and protectors, 2-dimethylaminoethanol was the most potent inhibitor of choline uptake and the most potent protector of both hematopoietic progenitor cells and murine L1210 leukemia cells. Two analogs that exhibited both potent protection and inhibition were 1-dimethylamino-2-propanol [108-16-7] and 2-ethylmethylaminoethanol [2893-43-8]. 2-Di-n-butylaminoethanol [102-81-8], while protecting against mechlorethamine cytotoxicity, was not an inhibitor of choline uptake. 2-(n-Butylmethylamino)ethanol [2893-48-3], while an inhibitor of choline uptake, was not a protector against mechlorethamine cytotoxicity. Addn. of 2-dimethylaminoethanol to mechlorethamine in a mole ratio of 1 did not improve survival of tumor-bearing mice beyond that of mice treated with mechlorethamine alone. .

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents.Some chemicals with cas registry numbers like 15663-27-1 and 23214-92-8 are also used. Ijiri, K.; Potten, C. S. (Fac. Sci., Univ. Tokyo, Tokyo 113, Japan). Br. J. Cancer, 55(2), 113-23 (English) 1987. CODEN: BJCAAI. ISSN: 0007-0920. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 8 Adult male mice were treated with 1 or 2 different doses of each of 18 different cytotoxic agents. They were sampled at various times (3-12 h) thereafter, and the spatial distributions of cell death in the small intestinal crypts were studied. Dead or dying cells or cells carrying dead cell fragments were examd. histol., and all of these were recorded (for convenience as apoptotic fragments), relative to the cell position in the crypt. Thus, distributions of apoptotic fragments against cell position were detd. A regression anal. of the data obtained at different times after administration of each cell position were detd. A regression anal. of the data obtained at different times after administration of each agent was undertaken and the position of the median of the spatial distribution of presumptive target cells was deduced for each cytotoxic agent. The accuracy of this median value was detd. to be ±0.5 cell positions. From these median values, the different cytotoxic agents could be divided roughly into 3 groups: 3H-labeled thymidine [50-89-5], isopropylmethanesulfonate [926-06-7], g-rays, bleomycin [11056-06-7] and adriamycin [23214-92-8] all have their median values (susceptible cells) at cell positions 4 to 6; bischlorethylnitrosourea [154-93-8], actinomycin D [50-76-0], cyclophosphamide [50-18-0], and cycloheximide [66-81-9] at cell positions 6-8; mechlorethamine [51-75-2], triethylenethiophosphoramide [52-24-4], vincristine [57-22-7], 5-fluorouracil [51-21-8], hydroxyurea [127-07-1] and methotrexate [59-05-2] at cell positions 8-11. The position of these medians was considered in relation to the killing of clonogenic cells. Preliminary studies on the distributions of dead cells after myleran [55-98-1], cis-platinum [15663-27-1] and heat (hyperthermia) are also reported. There is a general tendency for antibiotics and radiation to attack the lower cell positions in the crypt. Alkylating agents on the other hand have a somewhat broad spectrum of action. Antimetabolites and a microtubule dissocg. agent act on higher cell positions. No difference could be detected between 2 different forms (sources) of actinomycin D. The changes in the yields of apoptotic and mitotic cells with time and the migration velocities of cells in the crypts carrying apoptotic fragments after exposure to cytotoxics are also presented. .