Reference

Quality tests of commercial gefarnate fine granules and granule

Quality tests of commercial gefarnate fine granules and granule. Maeda, Masaki; Inoue, Chikako; Hotate, Takako; Narui, Reiko; Harada, Ako; Tanaka, Kumiko; Ishikura, Chiyoji (Bohsei Pharm., Isehara 259-11, Japan). Byoin Yakugaku, 10(3), 182-9 (Japanese) 1984. CODEN: BYYADW. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Quality tests were carried out on 10 different com. gefarnate (I) [51-77-4] granule prepns. which are used for treatment of gastric or duodenal ulcer. The availability in handling was evaluated for each prepn. by examns. of phys. properties, such as angle of repose, loose bulk d., packed bulk d., dispersibility and particle size distribution. The stability was also examd. by measuring content, hydrolysis rate, and peroxide value. In addn., the relation between the results and the methods of granulation was detd.; all the prepns. were within acceptable range in actual dispensing. But in 4 prepns. out of 10, the amt. of I decreased. Peroxide values of these prepns. were remarkably high, whereas the hydrolysis rate indicated no significant value when these were compared with other com. prepns. Therefore, the degrdn. process was mainly due to the oxidn. These 4 prepns. were produced by an extruding granulation procedure. I is degraded easily, and its prepns. may show great difference in pharmaceutical quality when produced in different techniques.

Changes in synthetic activity of sulfated mucosubstances in healing process of acetic acid ulcer in rats and effect of anti-ulcer agents

Changes in synthetic activity of sulfated mucosubstances in healing process of acetic acid ulcer in rats and effect of anti-ulcer agents. Suwa, Toshio; Fukushima, Kiyomi; Kyogoku, Kazuaki; Mori, Yo (Res. Cent., Taisho Pharm. Co., Ltd., Ohmiya, Japan). Jpn. J. Pharmacol., 34(4), 480-2 (English) 1984. CODEN: JJPAAZ. ISSN: 0021-5198. 56-85-9 and 64506-49-6 which are cas registry numbers of substances are two of reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 In rats with gastric ulcers induced by AcOH, antiulcer drugs such as SU-88 [64506-49-6] and gefarnate [51-77-4] increased the incorporation of sulfate into mucosubstances in damaged tissues, facilitating healing. Drug-induced sulfation was not noted in normal gastric tissue. .