Reference

Growth promotion

Growth promotion. Benson, Harvey D.; Grunwell, Joyce Francis; Johnston, John O'Neal; Petrow, Vladimir (Richardson-Merrell Inc., USA). U.S. US 4013762 22 Mar 1977, 6 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-56. NCL: 424242000. APPLICATION: US 76-684947 10 May 1976. DOCUMENT TYPE: Patent CA Section: 18 (Animal Nutrition) Section cross-reference(s): 32, 2 I promote the growth of ruminants and poultry without androgenizing effects. I can be administered by injection, implantation, in feed, or in drinking H2O. For example, 3,17-dioxoandrost-4-en-19-al (II) [968-49-0] was prepd. by oxidn. of 19-hydroxyandrost-4-ene-3,17-dione [510-64-5]. After treating 10-day old chicks s.c. for 6 days with 1.0, 10.0, or 30 .mu.g II/kg/day, the wt. gain was greater than in controls. No androgenic side effects were obsd. for II.

Site a which FSH regulates estradiol-17

Site a which FSH regulates estradiol-17.beta. biosynthesis in Sertoli cell preparations in culture. Dorrington, Jennifer H.; Fritz, I. B.; Armstrong, D. T. (Banting Best Dep. Med. Res. 50-28-2 and 2126-37-6 are cas registry numbers. These chemicals are also mentioned in this article., Univ. Toronto, Toronto, Ont., Can.). Mol. Cell. Endocrinol., 6(2), 117-22 (English) 1976. CODEN: MCEND6. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The ability of Sertoli cells isolated from testes of 20-day-old rats and maintained in primary culture to synthesize estradiol (I) [50-28-2] from a variety of exogenous substrates, progesterone [57-83-0], testosterone [58-22-0], androstenedione [63-05-8], 19-hydroxyandrostenedione [510-64-5], and 19-hydroxytestosterone [2126-37-6] in the presence and absence of FSH [9002-68-0] was examd. In the presence of each of the substrates alone for 24 h the rate of I synthesis was very low. FSH (5 .mu.g/mL) stimulated I synthesis 75-fold when added to medium contg. testosterone (5 .times. 10-7M) but caused only marginal stimulation when added to medium contg. progesterone (5 .times. 10-7M). Both FSH and dibutyryl cyclic AMP [362-74-3] stimulated the conversion of each of the substrates, androstenedione, 19-hydroxyandrostenedione, and 19-hydroxytestosterone to I, and the effects were similar to those obsd. in the presence of testosterone. I synthesis was stimulated by FSH in the presence of the C19 steroids, which are intermediates in the biosynthetic pathway, suggesting that FSH influences the conversion of androgens to estrogens, either directly or indirectly, at the aromatization step (i.e. the conversion of 19-hydroxylated androgens to estrogens). .