Detail of "51079-10-8"

Reference

Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (I) as a Highly Selective VEGF-R2/3 Inhibitor

All Rights Reserved. Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (I) as a Highly Selective VEGF-R2/3 Inhibitor. Peifer, Christian; Krasowski, Agata; Haemmerle, Nina; Kohlbacher, Oliver; Dannhardt, Gerd; Totzke, Frank; Schaechtele, Christoph; Laufer, Stefan (Department of Pharmacy, Eberhard Karls University, Tuebingen D-72076, Germany). Journal of Medicinal Chemistry, 49(25), 7549-7553 (English) 2006 American Chemical Society. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27 The authors report on selectivity profiling of I in a panel of 20 protein kinases and mol. modeling indicating I to be highly active and selective for VEGF-R2/3. Sequence alignment anal. and detailed insights into the ATP binding pockets of targeted protein kinases from the panel result in a unique structural architecture of VEGF-R2 mainly caused by the hydrophobic pocket I, detg. 147014-97-9 and 51079-10-8 which are cas registry numbers of substances are two of reagents here. the mol. basis for activity and selectivity of I. .

A simple synthesis of stable heterocyclic phosphorus ylides derived from NH-acids

A simple synthesis of stable heterocyclic phosphorus ylides derived from NH-acids. Yavari, Issa; Adib, Mehdi; Jahani-Mogaddam, Fatemeh; Sayahi, Mohammad Hossain (Department of Chemistry, University of Tarbiat Modarres, Tehran, Iran). 762-42-5 and 51079-10-8 are also occured in this study. Phosphorus, Sulfur and Silicon and the Related Elements, 177(3), 545-553 (English) 2002 Taylor & Francis Ltd.Several substances are used for example 120-72-9 which is its cas registry number. CODEN: PSSLEC. ISSN: 1042-6507. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 29 Cryst. phosphorus ylides are obtained in excellent yields from the addn. reaction between triphenylphosphine, di-Me acetylenedicarboxylate and strong NH-acids, such as 2-acetylpyrrole, indole, Et 3-indolylglyoxalate and N-benzyl-2-pyrrolylglyoxamate. Dynamic NMR effects are obsd. in the 1H NMR spectra of stabilized ylides obtained from 2-acetylpyrrole and indole (DG1 = 67.1 and 68.8 kJmol-1 resp.) and are attributed to restricted rotation around the carbon-carbon partial double bond resulting from conjugation of the ylide moiety with the adjacent carbonyl group. ..