Detail of "5123-55-7"

Reference

Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase

Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase. Njoroge, F. George; Vibulbhan, Bancha; Alvarez, Carmen S.; Bishop, W. Robert; Petrin, Joanne; Doll, Ronald J.; Girijavallabhan, V.; Ganguly, Ashit K. (Departments Chemistry Tumor Biology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA). Bioorganic & Medicinal Chemistry Letters, 6(24), 2977-2982 (English) 1996 Elsevier.Several reagents with their cas registry numbers 5123-55-7 and 131384-38-8 are used here. CODEN: BMCLE8. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 7 Novel tricyclic FPT inhibitors I (R = CH2NH2, Ph, Q, etc.) and II (R = Me, Bu, 4-O2NC6H4, CH2Ph, etc.) with submicromolar FPT activity are described. Greatly enhanced FPT activity is realized with phthaloyl derivatized amino compd. I (R = Q), which showed FPT inhibitory activity of IC50 = 0.66 mM. Sulfonamides II (R = CH:CH2, CH2Ph) were also found to be potent FPT inhibitors. SAR resulting from a variety of tricyclic amino acids and sulfonamide derivs. is discussed. .

Studies on the mechanisms of action of local anesthetics

Studies on the mechanisms of action of local anesthetics. Part 9.Several substances are used for example 61925-93-7 and 5123-55-7 which are their cas registry numbers. N-Aminoacyl-.beta.-phenylalkylamine studies for the development of antidepressants from psychostimulants. Schoenenberger, H.; Petter, A.; Beck, D.; Endres, W.; Servatius, H. J. (Inst. Pharm. Lebensmittelchem., Univ. Muenchen, Munich, Ger.). Pharmazie, 31(12), 882-6 (German) 1976. CODEN: PHARAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 25 Of 10 N-L-phenylalanyl-.beta.-phenylalkylamines[PhCH2CH(NH2)CONR3CH R2CHR1Ph] (I, R1 = H or OH; R2 and R3 = H or Me) prepd. and tested as antidepressants, I(R1 = H; R2 and R3 = Me) [61925-95-9] and I(R1 = OH; R2 = Me; R3 = H) (II) [61950-64-9] were the most active compds. in the inhibition of cond. in strips of frog heart ventrical, I(R1 and R3 = H; R2 = Me) (III) [61925-94-8] and II were the most active in potentiating the effect of noradrenaline in rat vas deferens. III showed cocaine-like activity, whereas II showed desipramine-like activity. .