Detail of "513-88-2"

Reference

Carcinogenic activity of haloacetonitriles and haloacetone derivatives in the mouse skin and lung

Carcinogenic activity of haloacetonitriles and haloacetone derivatives in the mouse skin and lung. Bull, R. J.; Robinson, M. (Health Eff. Res. Lab., Cincinnati, OH, USA). Report, EPA-600/D-84-185; Order No. PB84-215508, 19 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(21), 79 (English) 1984. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) The carcinogenicity in mouse skin and lung of chloro- [107-14-2], dichloro- [3018-12-0], trichloro- [545-06-2], bromochloro- [83463-62-1], and dibromoacetonitrile [3252-43-5] and of 1,1-dichloro- [513-88-2] and 1,1,1-trichloroacetone [918-00-3] was studied. The haloacetonitriles found in drinking water, with the possible exception of the dichloro compd., possessed carcinogenic properties. It was not possible to demonstrate such activity with the chlorinated acetones.

Studies of the toxic interactions of disinfection by-products

Studies of the toxic interactions of disinfection by-products. Laurie, R. Dana; Bercz, J. Peter; Wessendarp, Thomas K.; Condie, Lyman W. (Health Eff. Res. Lab., U. S. Environ. Prot. Agency, Cincinnati, OH 45268, USA). EHP, Environ. Health Perspect., 69, 203-7 (English) 1986. CODEN: EVHPAZ. ISSN: 0091-6765. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 60 Both the toxicity of the dichloropropanones and their potential interactions with a well-characterized haloalkane, CCl4 [56-23-5] were studied in mice. A variety of toxicol. and biochem. endpoints were used to evaluate the toxicity of the dichloropropanones and their interaction with CCl4, including cytochrome P 450 [9035-51-2] concn., GSH [70-18-8] levels, pentane generation, serum enzyme activities, and histopathol. Administration of 1,1-dichloropropanone (DCP) [513-88-2] resulted in elevated serum enzymes assocd. with periportal necrosis, GSH levels were reduced by the administation of 1,1-DCP; pentane generation was not increased. When 1,1-DCP was given prior to CCl4, the data were consistent with additivity. Administration of 1,3-DCP [534-07-6] did not result in elevated serum enzymes, nor was there histopathol. evidence of necrosis. GSH levels and pentane generation in the 1,3-DCP-treated groups were the same as those of controls. Inhibition of the toxicol. effects of CCl4 in a dose-related manner was obsd. when 1,3-DCP was administered prior to CCl4.