Reference

Tizanidine (DS103-282), a centrally acting muscle relaxant, selectively depresses excitation of feline dorsal horn neurons to noxious peripheral stimuli by an action at a2-adrenoceptors

Tizanidine (DS103-282), a centrally acting muscle relaxant, selectively depresses excitation of feline dorsal horn neurons to noxious peripheral stimuli by an action at a2-adrenoceptors. Davies, J.; Johnston, S. E.; Hill, D. R.; Quinlan, J. E. (Pharmacol. Dep., Sch. Pharm., London WC1N 1AX, UK). Neurosci. Lett., 48(2), 197-202 (English) 1984. CODEN: NELED5. ISSN: 0304-3940. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of microiontophoretic application of tizanidine [51322-75-9] were compared with those of adrenoceptor agonists on responses of single laminae IV and V neurons to noxious and innocuous cutaneous stimuli. Tizanidine, noradrenaline and clonidine depressed neuronal responses to noxious but not innocuous stimuli. Spontaneous activity was also depressed by these three substances. By contrast, b- and a1-adrenoceptor agonists had no consistent effect on neuronal responses to cutaneous stimuli. The selective actions of tizanidine, noradrenaline and clonidine were reversibly antagonized by the a2-adrenoceptor antagonist RX781094 but not by WB4101 (a1 antagonist). The binding of an a2-adrenoceptor ligand to rat brain membranes was preferentially displaced by tizanidine. These results indicate an interaction of tizanidine with central a2-adrenoceptors.

Analgesic preparations containing tizanidine and paracetamol

Analgesic preparations containing tizanidine and paracetamol. Roemer, Dietmar (Sandoz-Patent-G.m.b.H., Fed. Rep. Ger.). Ger. Offen. DE 3407579 A1 13 Sep 1984, 15 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-425; A61K031-48; A61K031-165. APPLICATION: DE 84-3407579 1 Mar 1984. PRIORITY: GB 83-6473 9 Mar 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) An improved and compatible analgesic prepn. (oral, suppository, etc.,) is prepd. from mixts. of tizanidine (I) [51322-75-9] and paracetamol [103-90-2] and shows no undesirable side effects. Tablets were prepd. each contg. tizanidine-HCl [64461-82-1] 2.3, paracetamol 250.00, corn starch 20.00, PVP 12.00, crosslinked PVP 15.00, lactose 88.71 and Mg stearate 2.00 mg.