Detail of "514-73-8"

Reference

Effect of cyanine and aminovinyl dyes on the peritoneal mast cells of rats

Effect of cyanine and aminovinyl dyes on the peritoneal mast cells of rats. Sugiyama, Katsumi; Utsumi, Kozo (Med. Sch., Okayama Univ., Okayama, Japan). Kanko Shikiso, 85, 36-42 (Japanese) 1976. CODEN: KASHAJ. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effect of cyanine and aminovinyl dyes on the compd. 48/80-induced degranulation and histamine [51-45-6] release by isolated rat mast cells was studied. Of 12 cyanine dyes tested, NK 76 (I; n = 1) [905-97-5], NK 136 (I; n = 2) [514-73-8], NK 19 (II; R = C7H15) [3571-88-8], NK 2251 [53213-94-8], NK 266 [37187-89-6], and NK 2252 [62008-59-7] inhibited the compd. 48/80-induced degranulation, whereas NK 88 (I; n = 0) [2197-01-5], NK 2 (II; R = Me) [37187-85-2], NK 2011 [62008-57-5], NK 1160 [62008-58-6], NK 1529 [62008-60-0] and NK 4 [4846-34-8] had no effect. All aminovinyl dyes (NK 343 [1463-95-2] and NK 355 [21034-17-3]) tested were without effect. NK 2251 also inhibited compd. 48/80- or ATP [56-65-5]-induced histamine release but had no effect on ATP-induced cell swelling. The mechanism of histamine release is discussed.

Carbocyanine dyes inhibit calcium-dependent potassium efflux from human red cell ghosts

Carbocyanine dyes inhibit calcium-dependent potassium efflux from human red cell ghosts. Simons, T. J. B. (Dep. Physiol., King's Coll., London, Engl.). Nature (London), 264(5585), 467-9 (English) 1976. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) A 0.33% human red cell ghost suspension (contg. intracellular Ca buffer and therefore highly permeable to K) was dyed with 280nM 3,3'-diethylthiadicarbocyanine iodide (I) [514-73-8] and the fluorescence was recorded; in K-free medium the ghosts showed a rapid depolarization to zero potential caused by I-induced decrease in membrane K permeability. The rate of depolarization decreased as the external K concn. increased; Rb and Cs ions prevented the depolarization obsd. in low K solns. whereas Na, Li, choline, and NEt4+ ions had no effect. Thus there appears to be a specific assocn. between I and the K transport system with the reaction apparently occurring on the membrane's external surface. 7440-70-2 and 3071-70-3 which are cas registry numbers of substances are two of reagents here. Other carbocyanine dyes (at 400nM concns.) were as effective as I in inhibiting net K efflux from Ca-contg. ghosts. Thus carbocyanine dyes should not be assumed to be inert probes of membrane potential; some of these dyes may be useful in the study of Ca-dependent K permeability systems. .