Detail of "515-46-8"

Reference

Nondepolarizing muscle relaxant

Nondepolarizing muscle relaxant. Khromov-Borisov, N. V.; Torf, S. F.; Cherepanova, V. P.; Danilov, A. F.; Starshinova, L. A. (USSR ). Ger. Offen. DE 2621227 17 Nov 1977,31 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-63. APPLICATION: DE 76-2621227 13 May 1976. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 25 Tercuronium (I) [65448-99-9] is a nondeploarizing muscle relaxant whose action is readily reversed by neostigmine [59-99-4]. I was 6-8-fold more active than d-tubocurarine and somewhat less active then pancuronium in lab animals. I had relatively little effects on arterial blood pressure, heart rate, sympathetic and parasympathetic ganglia, and muscarinic receptors, had low toxicity (with artificial respiration), and was compatible with anesthetics. During tracheal intubation, I administration (0.12-0.15 mg/kg i.v.) produced complete muscle relaxation lasting about 40 min. I was prepd. by redn. of 4,4''-dinitro-p-terphenyl [3282-11-9] with H2NNH2 and Raney Ni to 4,4''-diamino-p-terphenyl [3365-85-3], reaction of the product with EtI to form 4,4''-bis(diethylamino)-p-terphenyl [53693-66-6], and reaction of this compd. with Et benzenesulfonate [515-46-8].

Synthesis of cellulose ethers by etherification of alkali cellulose with aromatic sulfonic acid esters in a heterogeneous medium

Synthesis of cellulose ethers by etherification of alkali cellulose with aromatic sulfonic acid esters in a heterogeneous medium. Plisko, E. A.; Petrova, V. A.; Ivannikova, L. B. (Inst. Vysokomol. Soedin., Leningrad, USSR). Khim. Drev., (1), 89-92 (Russian) 1978. CODEN: KHDRDQ. DOCUMENT TYPE: Journal CA Section: 43 (Cellulose, Lignin, Paper, and Other Wood Products) Me [9004-67-5] and Et cellulose (I) [9004-57-3] with degree of substitution of 41-225 were prepd. by heterogeneous etherification of alkali cellulose [9081-58-7] with PhSO3Me [80-18-2] or PhSO3Et [515-46-8] at 60-80° for 2-8 h. The degree of substitution of I increased substantially with increasing temp. over the range 70-100°. I with degree of substitution 50-156 was prepd. by etherification of alkali cellulose with p-ClC6H4SO3Et [20443-71-4] or p-O2NC6H4SO3Et [15481-55-7] at 90-100° for 4 h. Both Me cellulose and I prepd. by etherification with arom. sulfonates are less homogeneous in compn. than the corresponding ethers prepd. by alkylation with MeCl or EtCl.