Reference

Analysis of subsidiary colors in D & C Red No

Analysis of subsidiary colors in D & C Red No. 9 and its purification: development of nonallergenic D & C Red No. 9. Naganuma, Masayuki; Ohtsu, Yutaka; Katsumura, Yoshio; Matsuoka, Masahiro; Morikawa, Yoshihiro; Tanaka, Muneo; Mitsui, Takeo (Shiseido Lab., Yokohama 223, Japan). J. Soc. Cosmet. Chem. 2387-08-8 and 7149-75-9 are cas registry numbers. These chemicals are also mentioned in this article., 34(6), 273-84 (English) 1983. CODEN: JSCCA5. ISSN: 0037-9832. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 41, 63 Anal. of com. D & C Red No. 9 [5160-02-1] revealed the presence of 11 arom. azo compds. (subsidiary colors) including SudanI (1-phenylazo-2-naphthol) [842-07-9], a strong sensitizer. In the modified guinea pig maximization test, each of the subsidiary colors was a contact sensitizer, whereas D & C Red No. 9 itself was not. Arom. amine impurities in Red Lake C Amine (2-amino-4-methyl-5-chlorobenzenesulfonic acid) [88-53-9] were the source of formation of the subsidiary colors in D & C Red No. 9. D & C Red No. 9 synthesized with Red Lake C Amine from which these arom. amines had been removed as completely as possible, contained no subsidiary colors. Based on these results, a practical manufg. process for D & C Red No. 9 free of contact sensitizers was developed, based on treating the Red Lake C Amine with activated C in aq. NaOH soln. before diazotization. .

Studies on the mutagenicity of cosmetic azo-dyes

Studies on the mutagenicity of cosmetic azo-dyes. Miyagoshi, Mamoru; Hayakawa, Yumiko; Nagayama, Tomio (Tokyo Coll. 3118-97-6 and 6371-76-2 are also occured in this study. Pharm., Tokyo 192-03, Japan). Eisei Kagaku, 29(4), 212-20 (Japanese) 1983. CODEN: ESKGA2. ISSN: 0013-273X. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) Section cross-reference(s): 4, 41 The cosmetic dyes Red 228 [2814-77-9] and Orange 203 [3468-63-1] were mutagenic, whereas Red 203 [2092-56-0], 204 [5160-02-1], 207 [1103-38-4], 221 [2425-85-6], and 505 [3118-97-6], Orange 205 [633-96-5], 403 [2646-17-5], and Yellow 401 [2512-29-0] were not. Some com. products contg. Red 201 [5858-81-1], 202 [5281-04-9], 219 [6371-76-2], and 220 [6417-83-0] were mutagenic, presumably due to contaminants. .