Reference

Antibiotic 7-[D-

Antibiotic 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol -5-ylthiomethyl)-3-cephem-4-carboxylic acid.In this study， 19856-23-6 and 62280-97-1 are also used. Granatek, Alphonse P.; Kaplan, Murray A. (Bristol-Myers Co., USA). Ger. Offen. DE 2622985 25 Nov 1976, 45 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-545. PRIORITY: US 75-580268 23 May 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Stable solid water-sol. antibiotic compns. which can be reconstituted with sterile H2O to form injection solns. contain one part of a 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol -5-ylthiomethyl)-3-cepham-4-carboxylic acid (I) [51627-14-6] as the hydrate or hydrochloride and 0.25-2.0 parts Ca, K or Na levulinate [19856-23-6]. For example, 10 g purified I methanolate was stirred in a soln. of 10 g levulinic acid in 20 mL H2O at 30-40.degree., the suspension was filtered, the filtrate was sterilized by filtration, and 7-8 g amorphous I monohydrate was pptd. by addn. of Me2CO. A mixt. of 0.250 g I monohydrate and 0.210 g sterile Na levulinate was milled to 60 mesh and placed in ampuls. This mixt. showed the same or better antibiotic activity when compared to cephalothin or cephalexin, and was less toxic to rabbit kidneys than a mixt. of I and Na pyruvate. .

Transport of cefatrizine (CFT

Transport of cefatrizine (CFT. Bricef) into milk after oral administration. Yamamoto, Takao; Yasuda, Jinsuke; Kaneo, Masaaki; Okada, Koji (Kyoto Prefect Med. Coll., Kyoto, Japan). Sanka to Fujinka, 50(12), 2137-40 (Japanese) 1983. CODEN: OBGYAR. ISSN: 0386-9792. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) After cefatrizine (I) [51627-14-6] (500 mg, orally) was given to women in lactation, the serum I concn. reached a max. at 2 h and slowly decreased for the following 4 h. However, the I levels in the milk were low. Apparently, the side effects of I on newborns are not significant.