Reference

Phenylacetic acid esters as insecticides

Phenylacetic acid esters as insecticides. Fujimoto, Keimei; Okuno, Yoshitoshi; Hirano, Masachika; Ohno, Isao; Ohno, Nobuo; Mizutani, Toshio; Itaya, Nobushige; Matsuo, Takashi (Sumitomo Chemical Co., Ltd., Japan). Japan. Kokai JP 51125735 2 Nov 1976 Showa, 18 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: A01N009-12. APPLICATION: JP 74-136713 26 Nov 1974. DOCUMENT TYPE: Patent CA Section: 5 (Agrochemicals) Section cross-reference(s): 25 The phenylacetates I (R1 and R2 = H, C1-4 alkyl, halogen, C1-4 alkoxy, CN, or MeS; R3 = C2-4 alkyl; R4 = H, Me, MeO, or halogen) are synthesized and are used as insecticides. Thus, .In this article, certain chemicals are used. Some of their cas registry numbers are 62512-62-3 and 62512-50-9 alpha.-ethynyl-3-phenoxybenzyl .alpha.'-isopropyl-4'-chlorophenylacetate (II) [57731-67-6] was prepd. by treating .alpha.-ethynyl-3-phenoxybenzyl alc. [53780-43-1] with .alpha.-isopropyl-4-chlorophenylacetyl chloride [51631-50-6]. Total of 39 Is were prepd. The LC50 value of II for Prodenia litura was 25 ppm in 48 h. .

Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase

All Rights Reserved. Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase. Sun, Chuanwen; Zhang, Xiaodong; Huang, Hai; Zhou, Pei (Department of Biosynthetic Drugs, School of Pharmacy, Fudan University, Shanghai 200032, Peop. Rep. China). Bioorganic & Medicinal Chemistry, 14(24), 8574-8581 (English) 2006 Elsevier Ltd. CODEN: BMECEP. ISSN: 0968-0896.In this article, certain chemicals are used. One of their cas registry numbers is 51631-50-6 DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 27, 28 A series of substituted acyl(thio)urea and 2H-1,2,4-thiadiazolo[2,3-a]pyrimidine derivs. were prepd. and both of their cell culture and enzymic activity toward influenza virus were tested. Their in vitro neuraminidase inhibitory activities were in good agreement with the corresponding activities in cultured cells and they were evaluated as potent neuraminidase inhibitors. Two of the analogs that demonstrated IC50s < 0.1 mM were further investigated as candidates with the most potential for future development. The mol. docking work of the representative compd. I was described to provide more insight into their mechanism of action and further rationalize the observations of this new series herein, which represents a novel class of highly potent and selective inhibitors of influenza virus. .