Detail of "51679-41-5"

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Some pharmacological effects of N-phenylanthranilic acid derivatives: Some pharmacological effects of N-phenylanthranilic acid derivatives. Danilenko, V. S.; Litvinov, V. B.; Mombuzhai, M. M. (Kiev. Nauchno-Issled. Inst. Farmakol.There are some reagents with their cas registry numbers 61-68-7 and 51679-41-5 are used in this study. Toksikol., Kiev, USSR). Fiziol. Akt. Veshchestva, 8, 83-5 (Russian) 1976. CODEN: FAVUAI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of the 8 N-phenylanthranilic acid derivs. tested, diethylaminoethyl p-difluoromethylthio-N-phenylanthranilate-HCl (I) [62498-76-4] had by far the greatest anticholinesterase activity, in that at 10-5M it inhibited by 84.3% horse serum cholinesterase [9001-08-5]in vitro. At 25-36 mg/kg i.p. I increased by 2-3 times hexenal sleep and by 1.2-1.4 times the duration of arecoline tremors in mice. At 25 mg/kg it inhibited a conditioned defensive reflex in rats, but this was probably a nonspecific effect of the compd. and not related to its anticholinesterase activity. .