Detail of "51827-01-1"

Reference

Comparison studies of neurotensin and xenopsin upon pancreatic secretion in the dog

Comparison studies of neurotensin and xenopsin upon pancreatic secretion in the dog. Ishida, T.; Kawamura, K.; Goto, A.; Nishina, Y.; Takahara, J.; Yamamoto, S.; Kawanishi, K.; Ofjui, T. (Med. Sch., Okayama Univ.Several reagents with their cas registry numbers 9004-10-8 and 9007-92-5 are used here., Okayama, Japan). Metab., Clin. Exp., 25(11, Suppl. 1), 1467-8 (English) 1976. CODEN: METAAJ. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In dogs, neurotensin [39379-15-2] (10 .mu.g/kg) injected into the pancreaticoduodenal artery caused a marked biphasic increase blood plasma insulin [9004-10-8] and proinsulin C-peptide [59112-80-0]. Plasma glucagon [9007-92-5] increased approx. 3-fold, plasma gastrin [9002-76-0] increased over 3 times, and plasma glucose increased about 17%. Xenopsin [51827-01-1] (10 .mu.g/kg) resulted in a smaller biphasic increase of insulin compared to neurotensin, but a similar response in glucagon secretion, accompanied by a rise in glucose of approx. 15%. Plasma gastrin increased up to 3 times. .

Stimulatory effect of neurotensin on insulin and gastrin secretion in dogs

Stimulatory effect of neurotensin on insulin and gastrin secretion in dogs. Ishida, Toshihiko (3rd Dep. Intern. Med., Okayama Univ. Med. Sch., Okayama, Japan). Endocrinol. Jpn., 24(4), 335-42 (English) 1977. CODEN: ECJPAE. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The effects of neurotensin [39379-15-2] on plasma insulin [9004-10-8] and gastrin [9002-76-0] secretion were investigated in 12 normal and 8 hypophysectomized dogs. Neurotensin was injected rapidly or infused for 30 min into the superior pancreaticoduodenal artery. In normal dogs, rapid administration of neurotensin (10 .mu.g/kg) brought about a mild hyperglycemia and a rapid and sharp increase of plasma insulin and gastrin levels. In the pancreatic vein, a biphasic insulin response was noted. The same secretory pattern of insulin was demonstrated during neurotensin (500 ng/kg/min) infusion. In the antral vein, the plasma gastrin level increased rapidly to 425% from basal level within 2 min and returned nearly to the initial level within 10 min after a rapid administration of neurotensin. In hypophysectomized dogs, the basal levels of plasma glucose, pancreatic insulin and antral gastrin were decreased to 53%, 9%, and 65% of normal dogs, resp. Neurotensin had little effect on insulin secretion, and a biphasic insulin secretory pattern obsd. in normal dogs was not demonstratedin hypophysectomized dogs. However, neurotensin-stimulated plasma gastrin concns. were considerably maintained. Also, xenopsin [51827-01-1] (10 .mu.g/kg) induced a milk hyperglycemia, hyperinsulinemia,and hypergastrinemia, but its secretory activities were smaller than those of neurotensin. Neurotensin apparently stimulates insulin and gastrin secretion by neurogenic vasodilatation or by a direct acion an pancreatic .beta.-cell and gastrin secretory cell of the gastric antrum.