Reference

Microreactor synthesis of b-peptides

All Rights Reserved. Several substances are used for example 51871-62-6 and 159991-23-8 which are their cas registry numbers. Microreactor synthesis of b-peptides. Floegel, Oliver; Codee, Jeroen D. C.; Seebach, Dieter; Seeberger, Peter H. (Laboratory of Organic Chemistry, Swiss Federal Institute of Technology Zuerich, Zurich 8093, Switz.). Angewandte Chemie, International Edition, 45(42), 7000-7003 (English) 2006 Wiley-VCH Verlag GmbH & Co. KGaA. CODEN: ACIEF5. ISSN: 1433-7851. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 47 The use of silicon-based microreactor for the effective peptide synthesis was demonstrated. The microstructured reaction device allowed for the detailed investigation and optimization of reaction parameters by using minimal amts. of reagents. The use of unusually high temps. (up to 120°C) reduces the reaction times. The insertion of a fluorous benzyl protecting group enhances the efficiency of the synthesis. The continuous flow process opens many opportunities for multistep synthesis and automation. .