CAS No.519-37-9,7-(2-HYDROXYETHYL)THEOPHYLLINE Suppliers

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Basic Information

Molecular Structure:
CAS No.:	519-37-9
Name:	7-(2-HYDROXYETHYL)THEOPHYLLINE
Article Data:	15

Formula:	C₉H₁₂N₄O₃
Molecular Weight:	224.219
Synonyms:	Theophylline,7-(2-hydroxyethyl)- (7CI,8CI);7-(2-Hydroxyethyl)-1,3-dimethylxanthine;7-(2-Hydroxyethyl)theophylline;7-(Hydroxyethyl)theophylline;7-(b-Hydroxyethyl)theophylline;7-Theophyllineethanol;Aethophyllinum;Ascorphylline;Bio-phylline;Cordalin;Corophyllin-N;Dilaphyllin;Etofylline;Etophyllin;Etophylline;Frekaphyllin;Hydroxyethyltheophylline;KT 200G;NSC 113373;Oxphylline;Oxyethophylline;Oxyethyltheophylline;Oxyphyllin;Oxyphylline;Oxytheonyl;Phyllocormin N;Soluphylline;
EINECS:	208-269-8
Density:	1.51 g/cm³
Melting Point:	163 °C
Boiling Point:	495.5 °C at 760 mmHg
Flash Point:	253.5 °C
Solubility:	2.991g/L(temperature not stated)
Hazard Symbols:	Xi,Xn
Risk Codes:	22-36/37/38
Safety:	36-36/37-26
PSA:	82.05000
LogP:	-1.57400

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Chemistry

Chemistry informtion about Hydroxyethyltheophylline (CAS NO.519-37-9) is:
IUPAC Name: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione
Synonyms: Etofylline ; Beta-Hydroxyethyltheophylline ; Biophylline ; 7-(A-Hydroxyethyl)Theophylline ; 7-(Beta-Hydroxyethyl)Theophylline ; 7-(2-Hydroxyethyl)Theophylline ; 1,3-Dimethyl-7-(Beta-Hydroxyethyl)Xanthine ; 1,3-Dimethyl-7-[2-Hydroxyethyl]-Xanthine
MF: C₉H₁₂N₄O₃
MW: 224.22
EINECS: 208-269-8
Melting Point: 163°C
Density: 1.51 g/cm³
Flash Point: 253.5 °C Boiling Point: 495.5 °C at 760 mmHg
Vapour Pressure: 1.23E-10 mmHg at 25°C
Enthalpy of Vaporization: 80.36 kJ/mol
Merck: 3878
Following is the molecular structure of Hydroxyethyltheophylline (CAS NO.519-37-9) is:

Uses

Hydroxyethyltheophylline (CAS NO.519-37-9) is useful synthetic intermediate in the preparation of 7-substituted xanthines.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	400mg/kg (400mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 190, 1958.
mouse	LD50	intravenous	344mg/kg (344mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
mouse	LD50	oral	400mg/kg (400mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977.
mouse	LD50	subcutaneous	400mg/kg (400mg/kg)	Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation skin and appendages (skin): sweating: other	Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954.
rat	LD50	intravenous	486mg/kg (486mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
rat	LD50	oral	710mg/kg (710mg/kg)	Liver: other changes	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980.
rat	LD50	subcutaneous	176mg/kg (176mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.

Safety Profile

Poison by ingestion, subcutaneous, intravenous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. See also THEOPHYLLINE.
Hazard Codes:
Xn: Harmful
Xi: Irritant
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S36: Wear suitable protective clothing.
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: XH5850000

Specification

Hydroxyethyltheophylline (CAS NO.519-37-9) is a white solid.