Detail of "51938-42-2"

Reference

Methods of modulating IL-6 using glycoalkaloids

Methods of modulating IL-6 using glycoalkaloids. Carter, Stephen John; Lake, Richard (Solbec Pharmaceuticals Co., Ltd., Australia). U.S. Pat. Appl. Publ. US 2005090453 A1 28 Apr 2005, 19 pp. (English). (United States of America). CODEN: USXXCO. CLASS: ICM: A61K031-7052. ICS: A61K031-58. APPLICATION: US 2004-758939 15 Jan 2004. PRIORITY: US 2003-2003/PV441060 15 Jan 2003. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) The present invention provides a method of reducing IL-6 prodn. comprising contacting an IL-6 producing cell with an effective amt. of a glycoalkaloid compn. The present invention also provides a method of disrupting the binding of IL-6 to its receptor comprising contacting the receptor or IL-6 with an effective amt. of a glycoalkaloid compn. In a related aspect, the present invention provides a method of reducing the proliferation of IL-6 producing cells comprising contacting said cells with an effective amt. of a glycoalkaloid compn. The present invention also provides methods for treating IL-6 related diseases and disorders. The glycoalkaloid compn. can be a Z Glycoalkaloid I (either one or both of dotted lines = double bond, and other single bond, or both = single bonds; A = II-V; R1 = H, amino, oxo, OR4; R1 = H, amino, OR4; R3 = H, carbohydrate, carbohydrate deriv.; X = CH2, O NH2; compd. includes .gtoreq.1 R4 that is carbohydrate or carbohydrate deriv.). 51938-42-2 which is the cas registry number is also used here. .