Reference

Permeation of drugs through artificial lipid membranes

Permeation of drugs through artificial lipid membranes. Part 16.Several substances are used for example 52-01-7 and 1672-46-4 which are their cas registry numbers. Behavior of neutral substances in very low concentrations. Fuerst, W.; Fuchs, G. (Sekt. Pharm., Martin-Luther-Univ. Halle-Wittenberg, Halle/Saale DDR-4020, Ger. Dem. Rep.). Pharmazie, 38(11), 794-5 (German) 1983. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The permeation of a lauryl alc.-collodion membrane in a vibration model app. by micro- and nanogram amts. of digoxigenin [1672-46-4] (representing cardiac glycosides) and the steroid prednisolone acetate [52-21-1] fits a 2-compartment model whereas the permeation by prednisone acetate [125-10-0], norethisterone acetate [51-98-9], and spironolactone [52-01-7] was described by a 3-compartment model with the membrane as the 3rd component. .

Chloramphenicol-prednisolone acetate combination: difference in the duration of action of the active components

Chloramphenicol-prednisolone acetate combination: difference in the duration of action of the active components. Toutain, P. L.; Koritz, G. D.; De Pomyers, H.; Alvinerie, M.; Ruckebusch, Y. (Station Pharmacol. Toxicol., INRA, Toulouse F-31300, Fr.). Rev. Med. Vet. (Toulouse), 134(10), 555-8 (French) 1983. CODEN: RVMVAH. ISSN: 0035-1555. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 18 Based on the pharmacokinetic data of chloramphenicol [56-75-7] and the adrenal suppressive effects of prednisolone acetate [52-21-1], it was shown that the duration of action of these active principles in a veterinary compn. is very different. The activity of the steroid persists at least 15 days after that of the antibiotic. The time for absorption of the steroid was 48 h as compared to 5 h for the antibiotic.