Detail of "52-43-7"

Reference

Behavior of barbituric acids towards phenothiazine drugs

Behavior of barbituric acids towards phenothiazine drugs. Carlotti, M. E.; Trotta, M.; Gasco, M. R. (Ist. Chim. Farm. Tossicol., Univ. Torino, Turin 10125, Italy). Pharm. Acta Helv., 59(1), 25-8 (English) 1984. CODEN: PAHEAA. ISSN: 0031-6865. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Chlorpromazine [50-53-3] and trifluperazine [117-89-5] micelles solubilized barbituric acids and the binding consts. for the 2 phenothiazines was similar; the binding consts. to the phenothiazine micelles at pH 5 or 5.8 and at 25° followed this order: phenobarbitone [50-06-6] > allobarbitone [52-43-7] > barbitone [57-44-3]. The binding of barbiturates to phenothiazines was verified by the gel filtration and diffusion methods. Increasing concns. of chlorpromazine and trifluperazine (at low concns., below the crit. micelle concns.) increased the diffusion rate const. of phenobarbitone at 37°. Ion pair formation between the phenothiazines and barbiturates was discussed.

The effect of barbiturates on the embryonic growth of cress seedlings (Lepidium sativum L

The effect of barbiturates on the embryonic growth of cress seedlings (Lepidium sativum L.). Buchbauer, G. (Pharm.-Chem. Inst., Univ. Wien, Vienna, Austria). Arzneim.-Forsch., 27(1), 161-5 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of 8 barbiturates selected for various chem. structures, phenobarbital (I) [50-06-6], cyclobarbital [52-31-3], and pentobarbital [57-33-0] at 10-3-10-4M markedly stimulated root growth by garden cress seedlings, whereas barbital [57-44-3], allobarbital [52-43-7], secobarbital [309-43-3], propallylonal [545-93-7], and barbituric acid [67-52-7] at the same concns. inhibited or only slightly stimulated root growth. At higher concns. (10-2-10-3M), all 8 compds. inhibited root growth. At these high concns., the inhibitory action of I was greater at pH 5 than at pH 7 or 8. Linear relations were found between, on the 1 hand, the mean inhibitory concns. of the resp. barbiturates and, on the other hand, literature data on distribution coeffs. 52-31-3 and 309-43-3 which are cas registry numbers of substances are two of reagents here. in the system Et2O-DMF-H2O, on adsorption to silica gel, and on animal toxicity. There was no linear relation between mean inhibitory concns. and pK values. Possible mechanisms of the root-growth effects of the barbiturates are discussed with respect to parallel cell actions in animals, relative to the use of plants in pharmacol. as alternative methods to animal expts. .