Reference

Thermal behavior of psychotherapeutic compounds

Thermal behavior of psychotherapeutic compounds.Some chemicals with cas registry numbers like 113-59-7 and 69-09-0 are also used. II. Amitriptyline hydrochloride, trihexyphenidyl hydrochloride, chlorpromazine hydrochloride, levomepromazine hydrochloride, and chlorprothixene. Masse, J.; Chauvet, A.; Malaviolle, R.; Sabon, F. (Lab. Chim. Gen. Miner., Fac. Pharm., Montpellier, Fr.). Trav. Soc. Pharm. Montpellier, 36(3), 209-17 (French) 1976. CODEN: TSPMA6. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 69, 75 Thermal properties were detd. for chlorprothixene [113-59-7], chlorpromazine-HCl [69-09-0], trihexyphenidyl-HCl [52-49-3], amitriptyline-HCl [549-18-8], and levomepromazine-HCl [1236-99-3] by thermomicroscopy and differential calorimetry. The melting enthalpy for each compd. was detd. Several compds. were polymorphic. .

Antagonism of diazepam against central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism

Antagonism of diazepam against central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism. Soubrie, P.; Simon, P.; Boissier, J. R. (Unite Neuropsychopharmacol., Paris, Fr.). Neuropharmacology, 15(12), 773-6 (English) 1976. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The increased activity obsd. in mice after i.p. administration of benztropine mesylate [132-17-2] (8 mg/kg), scopolamine-HBr [114-49-8] (2 mg/kg), atropine sulfate [55-48-1] (24 mg/kg), or trihexyphenidyl chlorhydrate [52-49-3] (8 mg/kg) was reduced by diazepam [439-14-5] (0.5, 1, or 2 mg/kg, i.p., concns. 56-12-2 and 439-14-5 which are cas registry numbers are also used here. at which diazepam did not itself inhibit activity); picrotoxin [124-87-8] (1 or 2 mg/kg, s.c.) antagonized all these diazepam effects. Neither thiosemicarbazide [79-19-6] (4-64 mg/kg, s.c.) nor strychnine [57-24-9] (0.25 and 0.5 mg/kg, s.c.) antagonized the inhibitory effects of diazepam. Picrotoxin (0.5, 1, or 2 mg/kg) did not modify the decrease in spontaneous activity caused by diazepam (4 mg/kg). Diazepam may therefore antagonize the hyperactivity induced by anticholinergic drugs through direct stimulation of GABA [56-12-2] receptors. This, however, is not involved in diazepam redn. of spontaneous activity. .