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Basic Information
| CAS No.: | 52-53-9 |
|---|---|
| Name: | Verapamil |
| Article Data: | 14 |
| Molecular Structure: | |
|
|
|
| Formula: | C27H38N2O4 |
| Molecular Weight: | 454.61 |
| Synonyms: | Valeronitrile,5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-(7CI,8CI);5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;CP 16533-1;Lekoptin;Iproveratril;D 365;R,S-Verapamil;NSC 272306NA;VPL;dl-Verapamil; |
| EINECS: | 200-145-1 |
| Density: | 1.058 g/cm3 |
| Melting Point: | 25°C |
| Boiling Point: | 586.1 °C at 760 mmHg |
| Flash Point: | 308.3 °C |
| Appearance: | Viscous, pale yellow oil. |
| Hazard Symbols: |
 C
|
| Risk Codes: | R14; R34; R37 |
| PSA: | 63.95000 |
| LogP: | 5.09308 |
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Verapamil
Chemistry
Synonyms: 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile;-2-isopropyl-;2-isopropyl-;4-dimethoxy-alpha-(1-methylethyl)-l)-;5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv;5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylval;5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;aleronitrile
Molecular Formula: C27H38N2O4
Molecular Weight: 454.6
Molecular Formula: C27H38N2O4
Molecular Weight: 454.6
History
Verapamil is a class 4 antiarrhythmic, more effective than digoxin in controlling ventricular rate, and was approved by the United States Food and Drug Administration in 1981.
Toxicity Data With Reference
| 1. | ivn-man TDLo:1429 µg/kg/5M-C:CVS,PUL,SKN | NEJMAG New England Journal of Medicine. 306 (1982),238. | ||
| 2. | orl-wmn TDLo:64 mg/kg | BMJOAE British Medical Journal. 2 (1978),1127. | ||
| 3. | orl-man TDLo:48 mg/kg/2W-I | NEJMAG New England Journal of Medicine. 306 (1982),612. | ||
| 4. | orl-man LDLo:83 mg/kg | AJEMEN American Journal of Emergency Medicine. 7 (1989),624. | ||
| 5. | ivn-man TDLo:1429 µg/kg/5M-C | NEJMAG New England Journal of Medicine. 306 (1982),238. | ||
| 6. | ivn-man TDLo:71 µg/kg | AHJOA2 American Heart Journal. 111 (1986),622. | ||
| 7. | ivn-cld TDLo:250 µg/kg/5M-C | AHJOA2 American Heart Journal. 106 (1983),145. | ||
| 8. | orl-rat LD50:163 mg/kg | EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 25 (1990),351. | ||
| 9. | ipr-rat LD50:67 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 31 (1981),1401. | ||
| 10. | ivn-rat LD50:7250 µg/kg | PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 22 (1988),123. |
Consensus Reports
ISOPTIN's consensus:
Cyanide and its compounds are on the Community Right-To-Know List.
Cyanide and its compounds are on the Community Right-To-Know List.
Safety Profile
ISOPTIN's safety:
A poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and CN−. See also NITRILES.
A poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and CN−. See also NITRILES.