Detail of "52-86-8"

MSDS Download
CAS Number:
52-86-8
Name:
1-Butanone,4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
Superlist Name:
Haloperidol
Molecular Structure:
Formula:
C₂₁H₂₃ClFNO₂
Molecular Weight:
375.90
Synonyms:
Butyrophenone,4-[4-(p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro- (6CI,8CI);4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone;4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone;Aloperidin;Bioperidolo;Brotopon;Dozic;Einalon S;Eukystol;Haldol;Haloperin;Keselan;McN-JR 1625;NSC 615296;Peluces;Serenace;Serenelfi;g-[4-(p-Chlorphenyl)-4-hydroxypiperidino]-p-fluorbutyrophenone;
EINECS:
200-155-6
Density:
1.239 g/cm³
Melting Point:
152 °C
Boiling Point:
529.034 °C at 760 mmHg
Flash Point:
273.75 °C
Appearance:
white crystalline powder
Hazard Symbols:
T
Risk Codes:
60-61-25-36/37/38-43
Safety:
53-26-36/37/39-45 Details
Transport Information:
UN 2811 6.1/PG 3

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Supplier Location
Supplier Location
- China (Mainland)(24)
- India(10)
- Germany(2)
- United States(1)
Business Type
Business Type
- Manufacturers(1)
- Trading Company(25)
Certificates
Certificates
- ISO(1)
- Production License (0)
Exhibitions
Exhibitions
- CPhI China

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

Postsynaptic receptors are not essential for dopaminergic feedback regulation: Postsynaptic receptors are not essential for dopaminergic feedback regulation. Di Chiara, G.; Porceddu, M. L.; Fratta, W.; Gessa, G. L. (Inst. Pharmacol., Univ. Cagliari, Cagliari, Italy). Nature (London), 267(5608), 270-2 (English) 1977. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Destruction of striatal dopamine [51-61-6]-sensitive adenylate cyclase [9012-42-4] by kainic acid (3 .mu.g, intrastriatally) did not modify dopamine concns. but increased 3,4-dihydroxyphenyl acetate (I) [102-32-9] levels by 100% in lesioned striatum. Homolateral turning obsd. 24 h after lesioning was stimulated by apomorphine-HCl [314-19-2] (0.1-0.5 mg/kg, s.c.) and reversed into contralateral turning by haloperidol [52-86-8] (0.3 mg/kg, i.p.). The increases in striatal I in response to haloperidol or fluphenazine-HCl [146-56-5] were higher in lesioned animals than in controls. I concns. were decreased by apomorphine in both control and lesioned striatum. Haloperidol and apomorphine were mutually antagonistic. An interaction with postsynaptic dopamine receptors is not essential for the changes in dopamine metab. produced by neuroleptics and apomorphine, suggesting that dopamine receptors are not essential for dopaminergic feedback regulation.

Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity: Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Creese, Ian; Burt, David R.; Snyder, Solomon H. (Dep. Pharmacol. Exp. Ther., Johns Hopkins Univ. Sch. Med., Baltimore, Md., USA). Science, 197(4303), 596-8 (English) 1977. CODEN: SCIEAS. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The binding of tritiated haloperidol [52-86-8] to rat striatal dopamine receptors increased after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which were behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding was associated with an increased no. of receptor sites with no change in their affinity.

Detail of "52-86-8"

1-Butanone,4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

Exhibitions

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

CAS No.52-86-8 Haloperidol

Reference