Reference

Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol

Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol. Kim, Kwon Ho; Jarowski, Charles I. (Coll. Pharm. Allied Health Prof., St. John's Univ., Jamaica, N. Y., USA). J. Pharm. Sci., 66(11), 1536-40 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The dissoln. of hydrocortisone (I) [50-23-7] into simulated intestinal fluid from lipid delivery systems followed second-order kinetics. As the ratio of I to lipid was increased from 1:1 to 1:6, the dissoln. rate decreased. Solvent deposition of solid solns. of I and lipid on lactose resulted in the enhancement of the dissoln. rate. For the 1:1 I-lipid solid solns., the rank order of the dissoln. rate was I-cholesteryl stearate [35602-69-8], I, I-cholesterol [57-88-5] I-cholesteryl acetate [604-35-3], I-cholesteryl palmitate [601-34-3], I-cholesteryl n-butyrate [521-13-1], I-cholesteryl laurate [1908-11-8], and I-cholesteryl n-decylate [1183-04-6]. A direct correlation was found between the dissoln. rate of I and the surface tension lowering of simulated intestinal fluid by the corticoid and various lipids.

Capillary gas chromatography/mass spectrometry of cholesteryl esters with negative ammonia chemical ionization

Capillary gas chromatography/mass spectrometry of cholesteryl esters with negative ammonia chemical ionization. Evershed, Richard P.; Goad, L. John (Dep. Biochem., Univ. Liverpool, Liverpool L69 3BX, UK). Biomed. Environ. Mass Spectrom., 14(3), 131-40 (English) 1987. CODEN: BEMSEN. ISSN: 0887-6134. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Mixts. of both synthetic and naturally occurring (human plasma) cholesteryl esters have been examd. by capillary gas chromatog./mass spectrometry (GC/MS). A magnetic sector mass spectrometer was used and a variety of ionization modes were assessed with a view to obtaining structural information on intact cholesteryl esters. By employing ammonia as reagent gas, with neg. ion scanning, spectra were produced from which the nature of steryl and fatty acyl moieties could be readily deduced. Analyses were performed at an ion source temp. of 300° in order to obtain the integrity of the gas chromatog.In this experiment, several chemicals are used like 604-35-3 and 521-13-1 profile. The technique described is of general use for the GC/MS anal. of steryl esters, particularly in conjunction with magnetic sector instruments. .