Detail of "521-35-7"

Reference

Thin-layer separation of cannabinoids from phytosterols and tobacco components

Thin-layer separation of cannabinoids from phytosterols and tobacco components. Boisio, Maria Luisa (Ist. Med. Leg. Assicurazioni, Univ. Genova, Genoa, Italy). Med. Leg. Assicur., 24(1-4), 45-60 (Italian) 1976. CODEN: MLASAR. ISSN: 0369-058X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 11 Cannabidiol (I) [13956-29-1], tetrahydrocannabinol [1972-08-3], cannabinol [521-35-7], and b-sitosterol [83-46-5] were sepd. from 1 another and from tobacco components by thin-layer chromatog. on silica gel, using 5 solvent systems. Two Cannabis sativa exts., and 1 tobacco ext. were analyzed. Quant. was carried out by gas chromatog.

Maternal cannabinoid exposure

Maternal cannabinoid exposure. Effects on spermatogenesis in male offspring. Dalterio, S. L.; DeRooij, D. G. (Health Sci. Cent., Univ. Texas, San Antonio, TX, USA). Int. J. Androl., 9(4), 250-8 (English) 1986. CODEN: IJANDP. ISSN: 0105-6263. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Maternal exposure to cannabinoids influenced spermatogenesis and fertility in their male offspring examd. at 60-80 days of age. Approx. 20% less spermatozoa were found in males whose mothers had received either the nonpsychoactive cannabinol (CBN) [521-35-7] or cannabidiol (CBD) [13956-29-1] on day 1 postpartum than drug-naive controls. Males exposed to the major psychoactive component of marijuana, D9-tetrahydrocannabinol (THC) [1972-08-3] appeared to have spermatozoa in nos. comparable to controls. This finding may be consistent with the addnl. observation that CBN or CBD, but not THC, reduced the percentage of successful impregnations by cannabinoid-exposed males. However, males exposed to each of these cannabinoids produced less liver offspring than controls. Plasma levels of testosterone [58-22-0] and LH [9002-67-9] were reduced in mice exposed to THC on day-12 of gestation, whereas testicular wt. was reduced in adult mice exposed either on day 12 of gestation to CBD or on day 1 postpartum to THC. Apparently, perinatal exposure to psychoactive and nonpsychoactive components of marijuana produces long-term disruption of testicular functions, including the spermatogenic as well as the steroidogenic components.