Reference

Pharmacokinetic behavior of cefsulodin and cefotiam singly or in combination following the intravenous injection of 1 gram

Pharmacokinetic behavior of cefsulodin and cefotiam singly or in combination following the intravenous injection of 1 gram. Fourtillan, J. B.; Bryskier, A.; Lefebvre, M. A.; Ingrand, I. (Cerom, Poitiers 86000, Fr.). Pathol. Biol., 32(5 bis), 501-5 (French) 1984. CODEN: PTBIAN. ISSN: 0031-3009. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacokinetic parameters obtained for cefsulodin [52152-93-9] and cefotiam [61622-34-2] in healthy subjects were the same whether the drugs were administered i.v. either individually or in combination. The lack of pharmacokinetic antagonism between the 2 drugs justifies their combined clin. application.

Influence of antibiotics on immunological parameters: significance in experimental infections

Influence of antibiotics on immunological parameters: significance in experimental infections. Gillissen, G.; Pusztai-Markos, Z. (Med. Fac., RWTH, Aachen, Fed. Rep. Ger.). Drugs Exp. Clin. Res., 10(11), 813-19 (English) 1984. CODEN: DECRDP. ISSN: 0378-6501. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The immunomodulating effect of 6 antibiotics (cefotaxime [63527-52-6], cefoxitin [35607-66-0], cefsulodin [52152-93-9], cefoperazone [62893-19-0], cefotetan [69712-56-7], cefmenoxime [65085-01-0]) were tested in mice using the plaque assay of Jerne, the footpad swelling test and the peritoneal clearance of microorganisms. The results were then compared with the effect in exptl. infections with Candida albicans. The expts. showed that the results with these antibiotics were not homogenous in all test models. Therefore, the immunomodulating activities of antibiotics must be examd. not only with respect to particular immunol. parameters, but also with a more complex system of exptl. infections to answer the predominant question of a possible clin. significance.