Reference

Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of Estracyt and its derivatives

Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of Estracyt and its derivatives.Some chemicals with cas registry numbers like 52205-73-9 and 50-28-2 are also used. Buchanan, L. J.; Riches, A. C. (Dep. Anat. Exp. Pathol., Univ. St. Andrews, St. Andrews, UK). Br. J. Cancer, 55(1), 47-51 (English) 1987. CODEN: BJCAAI. ISSN: 0007-0920. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 14 Testosterone [58-22-0]-induced DNA synthesis in cultured rat ventral prostate was used to compare the direct effects of Estracyt [4891-15-0] and Emcyt [52205-73-9] with that of their metabolite, estramustine [2998-57-4], and their carrier-hormone, estradiol-17b [50-28-2] on prostatic growth. In serum-supplemented medium (5-20% FCS), all the compds. were equally effective in suppressing testosterone-stimulated DNA synthesis which was reduced 40-50%, whereas in serum-free medium the estramustine compds. were consistently less effective than estradiol-17b. In the presence of 4 ′ 10-9M testosterone in serum-free medium, stimulated DNA synthesis was reduced by 15-30% following incubation with 4 ′ 10-7M of Estracyt, Emcyt, and estramustine and by 60% with 4 ′ 10-7M estradiol-17b. Thus, none of the estramustine compds. offer any selective advantage over that of estradiol-17b in suppressing prostatic DNA synthesis at the target tissue level. .

Hormone-anticancer drug conjugates

Hormone-anticancer drug conjugates. Osawa, Nakaaki (3rd Dep.In this study， 52205-73-9 and 75219-46-4 are also used. Intern. Med., Univ. Tokyo, Tokyo, Japan). Horumon to Rinsho, 34(10), 923-8 (Japanese) 1986. CODEN: HORIAE. ISSN: 0439-5875. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 2 A review, with 5 refs., on the pharmacol. and cytotoxic actions of estramustine Na phosphate (Estracyt [52205-73-9]) and bestrabucil [75219-46-4] (KM 2210), and their therapeutic uses. .