Reference

DNA damage and repair induced in rat hepatocyte primary cultures by five antihistamines and their nitrosation products

DNA damage and repair induced in rat hepatocyte primary cultures by five antihistamines and their nitrosation products. Martelli, A.; Cajelli, E.; Pino, A.; Robbiano, L.; Brambilla, G. (Inst. Pharmacol., Univ. Genoa, Genoa I-16132, Italy). IRCS Med. Sci., 12(11), 1054-5 (English) 1984.There are some reagents like 91-81-6 is used in this study. CODEN: IMSCE2. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Exposure of rat hepatocyte primary cultures to a non-toxic concn. of tripelennamine (I) [91-81-6] (100 mM for 5 or 20 h) resulted in a significant increase in DNA elution rate and DNA repair. Exposure of the cultures to non-toxic concns. of promethazine (II) [60-87-7], diphenhydramine [58-73-1], chlorphenoxamine [77-38-3], or dimenhydrinate [523-87-5] had no effect on hepatocyte DNA. Although all 5 antihistamines formed N-nitroso compds. in vitro, DNA fragmentation was detected only in the exposed to non-toxic dilns. of the nitrosation product of I [57830-36-1] and the nitrosation product of II [94511-44-1]. DNA repair synthesis was elicited only by the nitrosation product of I. These results are discussed with respect to the potential carcinogenic activity of H1-antihistamines and their nitrosation products. .

Discriminable effects of antihistamine drugs

Discriminable effects of antihistamine drugs. Overton, D. A. (Temple Med. Sch., Eastern Pennsylvania Psychiatr. Inst., Philadelphia, Pa., USA). Arch. Int. Pharmacodyn. Ther., 232(2), 221-6 (English) 1978. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Rats were trained to discriminate drug vs. no-drug in a shock-escape T-maze task; a right turn was required when rats were drugged and a left turn when undrugged. The 3 antihistamine drugs pyrilamine maleate [59-33-6], Dramamine (dimenhydrinate) [523-87-5] and Benadryl (diphenylhydramine-HCl) [147-24-0] were discriminated after an av. of 20 training sessions indicating that their effects were only moderately discriminable. After criterion performance was achieved under the training conditions, substitution tests were conducted during which rats received a novel drug and were then run in the maze with both goals accessible. Rats trained with antihistamine drugs made drug choices during tests with other antihistamines. Rats trained with other types of drugs made no-drug choices during tests with antihistamines. The results suggest that the antihistamines share a discriminable effect which is relatively unique to that class of drugs.