Reference

Pharmaceutical composition containing dimethylaminoethanol derivatives of drugs

Irrgang, Karl; El Agamy, Mohammed Riffaat (Stada Arzneimittel A.-G., Ger.). Ger. Offen.Several substances are used for example 52461-61-7 which is its cas registry number. DE 2709531 7 Sep 1978, 29 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K045-08. APPLICATION: DE 77-2709531 4 Mar 1977. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Proton-releasing drug dimethylaminoethanol derivs. and precursors of these derivs. are prepd. and show improved therapeutic indexes and fewer side effects than the original drugs. For example, dimethylaminoethanol salicylate (I) [68141-46-8] was prepd. from the alc. and acid and showed a greater antiphlogistic activity against formalin-induced rat foot edema than salicylic acid, Na salicylate or aspirin when administered orally. I could be compounded as hard gelatin capsules, tablets or injections, and showed good gastric tolerance. .