Detail of "525-97-3"

CAS Number:
525-97-3
Name:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-6-[(1-oxooctyl)amino]-, (2S,5R,6R)-
Molecular Structure:
Formula:
C16H26 N2 O4 S
Molecular Weight:
0
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-octanamido-7-oxo- (7CI,8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(1-oxooctyl)amino]-, [2S-(2a,5a,6b)]-; Penicillin K (6CI);Heptylpenicillin; Octanoylpenicillin; Penicillin A; Penicillin, heptyl-
Density:
1.25g/cm³
Boiling Point:
602.1°Cat760mmHg
Flash Point:
317.9°C

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The role of a protein that binds penicillin with slow kinetics in physiology and response to penicillin of Streptococcus faecium ATCC 9790: The role of a protein that binds penicillin with slow kinetics in physiology and response to penicillin of Streptococcus faecium ATCC 9790. Fontana, Roberta; Canepari, Piero; Satta, Giuseppe (Ist. Microbiol., Univ. Padova, Padua 35100, Italy). 525-97-3 are also occured in this study. Target Penicillin: Murein Sacculus Bact. Cell Walls Archit. Growth, Proc., Int. FEMS Symp., 531-6. Edited by: Hakenbeck, Regine; Hoeltje, Joachim-Volker; Labischinski, Harald. de Gruyter: Berlin, Fed. Rep. Ger. (English) 1983. CODEN: 50ODAA. DOCUMENT TYPE: Conference CA Section: 10 (Microbial Biochemistry) Penicillin-resistant mutants of S. faecium, obtained by serial passages in medium contg. increasing antibiotic concns., overproduced penicillin-binding protein (PBP) 5, which bound penicillin with kinetics much slower than those for the other PBPs. All resistant mutants showed an increased amt. of PBP 5 that paralleled the increase in penicillin resistance. The resistant strains continued to grow normally in the presence of penicillin concns. that satd. all PBPs other than PBP 5 and stopped growing only in the presence of concns. that satd. PBP 5. PBP 5 may be the killing target for penicillin in S. faecium. .

Direct enzymic synthesis of natural penicillins using phenylacetyl-CoA:6-APA phenylacetyltransferase of Penicillium chrysogenum: minimal and maximal side chain length requirements: Direct enzymic synthesis of natural penicillins using phenylacetyl-CoA:6-APA phenylacetyltransferase of Penicillium chrysogenum: minimal and maximal side chain length requirements. Luengo, Jose M.; Iriso, Jose L.; Lopez-Nieto, M. J. (Planta Piloto Ferment., Antibioticos S.A., Leon, Spain). J. Antibiot., 39(12), 1754-9 (English) 1986. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 16 (Fermentation and Bioindustrial Chemistry) In vitro synthesis of different natural penicillins (hexanoyl- [4493-18-9], heptanoyl- [18991-48-5], and octanoylpenicillin [525-97-3]) was carried out by direct acylation of 6-aminopenicillanic acid [551-16-6] with several fatty acid-CoA derivs. 4493-18-9 and 525-97-3 which are cas registry numbers of chemicals are mentioned. (hexanoyl-CoA, heptanoyl-CoA and octanoyl-CoA). The reactions were catalyzed by Acyl-CoA:6-aminopenicillanic acid acyltransferase [54576-90-8] from P. chrysogenum AS-P-78. This enzyme only accepts as substrate aliph. side chain precursors with carbon length of 6-8 atoms. Although the enzymic synthesis of octanoylpenicillin has been previously reported the in vitro synthesis of hexanoyl- and heptanoylpenicillins is described for the 1st time. .